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Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials()
It is unknown whether a novel small-quantity lipid-based nutrient supplement (SQ-LNS) containing alpha-linolenic (ALA) and linoleic acids impacts maternal plasma lipids and fatty acid status. We measured plasma fatty acids (wt%) and lipid concentrations at 36 wk gestation and breast milk fatty acids...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Churchill Livingstone
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338685/ https://www.ncbi.nlm.nih.gov/pubmed/28237085 http://dx.doi.org/10.1016/j.plefa.2017.01.007 |
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author | Oaks, Brietta M. Young, Rebecca R. Adu-Afarwuah, Seth Ashorn, Ulla Jackson, Kristina H. Lartey, Anna Maleta, Kenneth Okronipa, Harriet Sadalaki, John Baldiviez, Lacey M. Shahab-Ferdows, Setti Ashorn, Per Dewey, Kathryn G. |
author_facet | Oaks, Brietta M. Young, Rebecca R. Adu-Afarwuah, Seth Ashorn, Ulla Jackson, Kristina H. Lartey, Anna Maleta, Kenneth Okronipa, Harriet Sadalaki, John Baldiviez, Lacey M. Shahab-Ferdows, Setti Ashorn, Per Dewey, Kathryn G. |
author_sort | Oaks, Brietta M. |
collection | PubMed |
description | It is unknown whether a novel small-quantity lipid-based nutrient supplement (SQ-LNS) containing alpha-linolenic (ALA) and linoleic acids impacts maternal plasma lipids and fatty acid status. We measured plasma fatty acids (wt%) and lipid concentrations at 36 wk gestation and breast milk fatty acids (wt%) at 6 months postpartum in a subsample of women enrolled in a randomized controlled trial studying the effects of SQ-LNS on birth outcomes and child growth. Women≤20 wk gestation in Ghana (n=1,320) and Malawi (n=1,391) were assigned to receive daily either: 1) iron-folic acid (pregnancy); 2) multiple micronutrients (pregnancy and lactation); or 3) SQ-LNS (pregnancy and lactation). At 36 wk, plasma ALA levels were higher in those receiving SQ-LNS. SQ-LNS increased breast milk ALA in Ghana but not Malawi. There was no effect on plasma lipids or other selected fatty acids. SQ-LNS may impact plasma and breast milk ALA levels depending on the population. |
format | Online Article Text |
id | pubmed-5338685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Churchill Livingstone |
record_format | MEDLINE/PubMed |
spelling | pubmed-53386852017-03-13 Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials() Oaks, Brietta M. Young, Rebecca R. Adu-Afarwuah, Seth Ashorn, Ulla Jackson, Kristina H. Lartey, Anna Maleta, Kenneth Okronipa, Harriet Sadalaki, John Baldiviez, Lacey M. Shahab-Ferdows, Setti Ashorn, Per Dewey, Kathryn G. Prostaglandins Leukot Essent Fatty Acids Article It is unknown whether a novel small-quantity lipid-based nutrient supplement (SQ-LNS) containing alpha-linolenic (ALA) and linoleic acids impacts maternal plasma lipids and fatty acid status. We measured plasma fatty acids (wt%) and lipid concentrations at 36 wk gestation and breast milk fatty acids (wt%) at 6 months postpartum in a subsample of women enrolled in a randomized controlled trial studying the effects of SQ-LNS on birth outcomes and child growth. Women≤20 wk gestation in Ghana (n=1,320) and Malawi (n=1,391) were assigned to receive daily either: 1) iron-folic acid (pregnancy); 2) multiple micronutrients (pregnancy and lactation); or 3) SQ-LNS (pregnancy and lactation). At 36 wk, plasma ALA levels were higher in those receiving SQ-LNS. SQ-LNS increased breast milk ALA in Ghana but not Malawi. There was no effect on plasma lipids or other selected fatty acids. SQ-LNS may impact plasma and breast milk ALA levels depending on the population. Churchill Livingstone 2017-02 /pmc/articles/PMC5338685/ /pubmed/28237085 http://dx.doi.org/10.1016/j.plefa.2017.01.007 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Oaks, Brietta M. Young, Rebecca R. Adu-Afarwuah, Seth Ashorn, Ulla Jackson, Kristina H. Lartey, Anna Maleta, Kenneth Okronipa, Harriet Sadalaki, John Baldiviez, Lacey M. Shahab-Ferdows, Setti Ashorn, Per Dewey, Kathryn G. Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials() |
title | Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials() |
title_full | Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials() |
title_fullStr | Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials() |
title_full_unstemmed | Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials() |
title_short | Effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: Results of two randomized controlled trials() |
title_sort | effects of a lipid-based nutrient supplement during pregnancy and lactation on maternal plasma fatty acid status and lipid profile: results of two randomized controlled trials() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338685/ https://www.ncbi.nlm.nih.gov/pubmed/28237085 http://dx.doi.org/10.1016/j.plefa.2017.01.007 |
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