Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding

The developmental mechanisms regulating the number of adult neural stem cells (aNSCs) are largely unknown. Here we show that the cleavage plane orientation in murine embryonic radial glia cells (RGCs) regulates the number of aNSCs in the lateral ganglionic eminence (LGE). Randomizing spindle orienta...

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Detalles Bibliográficos
Autores principales: Falk, Sven, Bugeon, Stéphane, Ninkovic, Jovica, Pilz, Gregor-Alexander, Postiglione, Maria Pia, Cremer, Harold, Knoblich, Jürgen A., Götz, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338691/
https://www.ncbi.nlm.nih.gov/pubmed/28231465
http://dx.doi.org/10.1016/j.neuron.2017.02.009

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