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NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study

Multiple myeloma (MM) is an incurable malignancy of mature B-lymphoid cells, and its pathogenesis is only partially understood. Previous studies have demonstrated that a number of Non-Hodgkin Lymphoma (NHL) associated genes also show susceptibility to MM, suggesting malignancies originating from B c...

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Autores principales: Peng, Mengle, Zhao, Guanfei, Yang, Funing, Cheng, Guixue, Huang, Jing, Qin, Xiaosong, Liu, Yong, Wang, Qingtao, Li, Yongzhe, Qin, Dongchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338790/
https://www.ncbi.nlm.nih.gov/pubmed/28264017
http://dx.doi.org/10.1371/journal.pone.0173298
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author Peng, Mengle
Zhao, Guanfei
Yang, Funing
Cheng, Guixue
Huang, Jing
Qin, Xiaosong
Liu, Yong
Wang, Qingtao
Li, Yongzhe
Qin, Dongchun
author_facet Peng, Mengle
Zhao, Guanfei
Yang, Funing
Cheng, Guixue
Huang, Jing
Qin, Xiaosong
Liu, Yong
Wang, Qingtao
Li, Yongzhe
Qin, Dongchun
author_sort Peng, Mengle
collection PubMed
description Multiple myeloma (MM) is an incurable malignancy of mature B-lymphoid cells, and its pathogenesis is only partially understood. Previous studies have demonstrated that a number of Non-Hodgkin Lymphoma (NHL) associated genes also show susceptibility to MM, suggesting malignancies originating from B cells may share similar genetic susceptibility. Several recent large-scale genome-wide association studies (GWAS) have identified HLA-I, HLA-II, CXCR5, ETS1, LPP and NCOA1 genes as genetic risk factors associated with NHL, and this study aimed to investigate whether these genes polymorphisms confer susceptibility with MM in the Chinese Han population. In 827 MM cases and 709 healthy controls of Chinese Han, seven single nucleotide polymorphisms (SNPs) in the HLA–I region (rs6457327), the HLA–II region (rs2647012 and rs7755224), the CXCR5 gene (rs4938573), the ETS1 gene (rs4937362), the LPP gene (rs6444305), and the NCOA1 region (rs79480871) were genotyped using the Sequenom platform. Our study indicated that genotype and allele frequencies of rs79480871 showed strong associations with MM patients (p(a) = 3.5×10(−4) and p(a) = 1.5×10(−4)), and the rs6457327 genotype was more readily associated with MM patients than with controls (p(a) = 4.9×10(−3)). This study was the first to reveal the correlation between NCOA1 gene polymorphisms and MM patients, indicating that NCOA1 might be a novel susceptibility gene for MM patients in the Chinese Han population.
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spelling pubmed-53387902017-03-10 NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study Peng, Mengle Zhao, Guanfei Yang, Funing Cheng, Guixue Huang, Jing Qin, Xiaosong Liu, Yong Wang, Qingtao Li, Yongzhe Qin, Dongchun PLoS One Research Article Multiple myeloma (MM) is an incurable malignancy of mature B-lymphoid cells, and its pathogenesis is only partially understood. Previous studies have demonstrated that a number of Non-Hodgkin Lymphoma (NHL) associated genes also show susceptibility to MM, suggesting malignancies originating from B cells may share similar genetic susceptibility. Several recent large-scale genome-wide association studies (GWAS) have identified HLA-I, HLA-II, CXCR5, ETS1, LPP and NCOA1 genes as genetic risk factors associated with NHL, and this study aimed to investigate whether these genes polymorphisms confer susceptibility with MM in the Chinese Han population. In 827 MM cases and 709 healthy controls of Chinese Han, seven single nucleotide polymorphisms (SNPs) in the HLA–I region (rs6457327), the HLA–II region (rs2647012 and rs7755224), the CXCR5 gene (rs4938573), the ETS1 gene (rs4937362), the LPP gene (rs6444305), and the NCOA1 region (rs79480871) were genotyped using the Sequenom platform. Our study indicated that genotype and allele frequencies of rs79480871 showed strong associations with MM patients (p(a) = 3.5×10(−4) and p(a) = 1.5×10(−4)), and the rs6457327 genotype was more readily associated with MM patients than with controls (p(a) = 4.9×10(−3)). This study was the first to reveal the correlation between NCOA1 gene polymorphisms and MM patients, indicating that NCOA1 might be a novel susceptibility gene for MM patients in the Chinese Han population. Public Library of Science 2017-03-06 /pmc/articles/PMC5338790/ /pubmed/28264017 http://dx.doi.org/10.1371/journal.pone.0173298 Text en © 2017 Peng et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Peng, Mengle
Zhao, Guanfei
Yang, Funing
Cheng, Guixue
Huang, Jing
Qin, Xiaosong
Liu, Yong
Wang, Qingtao
Li, Yongzhe
Qin, Dongchun
NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study
title NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study
title_full NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study
title_fullStr NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study
title_full_unstemmed NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study
title_short NCOA1 is a novel susceptibility gene for multiple myeloma in the Chinese population: A case-control study
title_sort ncoa1 is a novel susceptibility gene for multiple myeloma in the chinese population: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338790/
https://www.ncbi.nlm.nih.gov/pubmed/28264017
http://dx.doi.org/10.1371/journal.pone.0173298
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