Cargando…

Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design

Among broadly neutralizing antibodies to HIV, 10E8 exhibits greater neutralizing breadth than most. Consequently, this antibody is the focus of prophylactic/therapeutic development. The 10E8 epitope has been identified as the conserved membrane proximal external region (MPER) of gp41 subunit of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Irimia, Adriana, Serra, Andreia M., Sarkar, Anita, Jacak, Ronald, Kalyuzhniy, Oleksandr, Sok, Devin, Saye-Francisco, Karen L., Schiffner, Torben, Tingle, Ryan, Kubitz, Michael, Adachi, Yumiko, Stanfield, Robyn L., Deller, Marc C., Burton, Dennis R., Schief, William R., Wilson, Ian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338832/ https://www.ncbi.nlm.nih.gov/pubmed/28225819 http://dx.doi.org/10.1371/journal.ppat.1006212

Ejemplares similares

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design
por: Jardine, Joseph G., et al.
Publicado: (2016)

Correction: Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design
por: Jardine, Joseph G., et al.
Publicado: (2016)

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies
por: Steichen, Jon M., et al.
Publicado: (2016)

Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan
por: Umotoy, Jeffrey, et al.
Publicado: (2019)

RosettaAntibodyDesign (RAbD): A general framework for computational antibody design
por: Adolf-Bryfogle, Jared, et al.
Publicado: (2018)

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies
por: Briney, Bryan, et al.
Publicado: (2016)

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding
por: Kulp, Daniel W., et al.
Publicado: (2017)

Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors
por: Willis, Jordan R., et al.
Publicado: (2022)

Structural basis of broad HIV neutralization by a vaccine-induced cow antibody
por: Stanfield, Robyn L., et al.
Publicado: (2020)

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
por: Sok, Devin, et al.
Publicado: (2017)

Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
por: Huang, Deli, et al.
Publicado: (2020)

Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
por: Huang, Deli, et al.
Publicado: (2020)

Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice
por: Melzi, Eleonora, et al.
Publicado: (2022)

Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope
por: Azoitei, Mihai L., et al.
Publicado: (2012)

Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer
por: Lee, Jeong Hyun, et al.
Publicado: (2022)

Global site-specific N-glycosylation analysis of HIV envelope glycoprotein
por: Cao, Liwei, et al.
Publicado: (2017)

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models
por: Huang, Deli, et al.
Publicado: (2020)

Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer
por: He, Linling, et al.
Publicado: (2017)

Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors
por: Luo, Sai, et al.
Publicado: (2022)

Correction for Khan et al., “Targeting the HIV-1 Spike and Coreceptor with Bi- and Trispecific Antibodies for Single-Component Broad Inhibition of Entry”
por: Khan, Salar N., et al.
Publicado: (2019)

Engineered mice and B cell lines expressing broadly neutralizing antibodies and their unmutated precursors: tools for HIV vaccinology
por: Nemazee, D, et al.
Publicado: (2012)

Combined Metagratings for Efficient Broad-Angle Scattering Metasurface
por: Neder, Verena, et al.
Publicado: (2019)

Proof of principle for epitope-focused vaccine design
por: Correia, Bruno E., et al.
Publicado: (2014)

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans
por: Julien, Jean-Philippe, et al.
Publicado: (2013)

Rational immunogen design to target specific germline B cell receptors
por: Jardine, J, et al.
Publicado: (2012)

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
por: Sok, Devin, et al.
Publicado: (2013)

Reproducing the hierarchy of disorder for Morpho-inspired, broad-angle color reflection
por: Song, Bokwang, et al.
Publicado: (2017)

Correction: The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
por: Sok, Devin, et al.
Publicado: (2013)

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies
por: McCoy, Laura E., et al.
Publicado: (2015)

P05-12. A computationally designed immunogen elicits potent anti-V3 neutralizing antibodies
por: Carrico, CT, et al.
Publicado: (2009)

P05-09. 4e10 epitope-scaffolds mimic the antibody-bound epitope conformation and block neutralization by sera from rare HIV+ individuals
por: Ban, YA, et al.
Publicado: (2009)

Broadband and Broad-Angle Low-Scattering Metasurface Based on Hybrid Optimization Algorithm
por: Wang, Ke, et al.
Publicado: (2014)

Broadband and Broad-angle Polarization-independent Metasurface for Radar Cross Section Reduction
por: Sun, Hengyi, et al.
Publicado: (2017)

Long-primed germinal centres with enduring affinity maturation and clonal migration
por: Lee, Jeong Hyun, et al.
Publicado: (2022)

Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration
por: Lee, Jeong Hyun, et al.
Publicado: (2023)

Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies
por: Julien, J, et al.
Publicado: (2012)

Development of prophylactic vaccines against HIV-1
por: Schiffner, Torben, et al.
Publicado: (2013)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

Efficient isolation of rare B cells using next-generation antigen barcoding
por: Hurtado, Jonathan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_mo1v260m45noi3uftmn63h0riu