Cargando…

Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle

BACKGROUND: The mechanism underlying nonsevere and severe asthma remains unclear, although it is commonly associated with increased airway smooth muscle (ASM) mass. Long noncoding RNAs (lncRNAs) are known to be important in regulating healthy primary airway smooth muscle cells (ASMCs), whereas chang...

Descripción completa

Detalles Bibliográficos
Autores principales:	Austin, Philip J., Tsitsiou, Eleni, Boardman, Charlotte, Jones, Simon W., Lindsay, Mark A., Adcock, Ian M., Chung, Kian Fan, Perry, Mark M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mosby 2017
Materias:	Asthma and Lower Airway Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338875/ https://www.ncbi.nlm.nih.gov/pubmed/27484035 http://dx.doi.org/10.1016/j.jaci.2016.06.014

Ejemplares similares

Quantitative computed tomography–derived clusters: Redefining airway remodeling in asthmatic patients()
por: Gupta, Sumit, et al.
Publicado: (2014)

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms
por: Hinks, Timothy S.C., et al.
Publicado: (2015)

Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?(⋆)()
por: Birrell, Mark A., et al.
Publicado: (2014)

Theophylline inhibits the cough reflex through a novel mechanism of action()
por: Dubuis, Eric, et al.
Publicado: (2014)

D prostanoid receptor 2 (chemoattractant receptor–homologous molecule expressed on T(H)2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells
por: Stinson, Sally E., et al.
Publicado: (2015)

Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease
por: Löser, Stephan, et al.
Publicado: (2017)

Propagation of respiratory viruses in human airway epithelia reveals persistent virus-specific signatures
por: Essaidi-Laziosi, Manel, et al.
Publicado: (2018)

Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice
por: Lively, Tricia N., et al.
Publicado: (2008)

Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study
por: Hartley, Ruth A., et al.
Publicado: (2016)

Mothers' anxiety during pregnancy is associated with asthma in their children
por: Cookson, Hannah, et al.
Publicado: (2009)

Host and viral factors associated with severity of human rhinovirus–associated infant respiratory tract illness
por: Miller, E. Kathryn, et al.
Publicado: (2011)

Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children
por: Sonnenschein-van der Voort, Agnes M.M., et al.
Publicado: (2014)

Alternaria-derived serine protease activity drives IL-33–mediated asthma exacerbations
por: Snelgrove, Robert J., et al.
Publicado: (2014)

Influence of childhood growth on asthma and lung function in adolescence
por: Sonnenschein-van der Voort, Agnes M.M., et al.
Publicado: (2015)

Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33
por: Castanhinha, Susana, et al.
Publicado: (2015)

Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-γ(high) immunophenotypes: Potential benefits of calcitriol
por: Chambers, Emma S., et al.
Publicado: (2015)

Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years
por: Simpson, Angela, et al.
Publicado: (2015)

Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease
por: Ghebre, Michael A., et al.
Publicado: (2015)

Associations of wheezing phenotypes with late asthma outcomes in the Avon Longitudinal Study of Parents and Children: A population-based birth cohort
por: Granell, Raquel, et al.
Publicado: (2016)

Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles
por: Ghebre, Michael A., et al.
Publicado: (2018)

Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function
por: Andersson, Cecilia K., et al.
Publicado: (2017)

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3–like protein 1
por: Hinks, Timothy S.C., et al.
Publicado: (2016)

Asthma among hospitalized patients with COVID-19 and related outcomes
por: Lovinsky-Desir, Stephanie, et al.
Publicado: (2020)

Type 2–high asthma is associated with a specific indoor mycobiome and microbiome
por: Vandenborght, Louise-Eva, et al.
Publicado: (2021)

Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode
por: Jartti, Tuomas, et al.
Publicado: (2015)

Association between respiratory infections in early life and later asthma is independent of virus type
por: Bønnelykke, Klaus, et al.
Publicado: (2015)

Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing
por: Mansbach, Jonathan M., et al.
Publicado: (2020)

Deletion of IL-4Rα signaling on B cells limits hyperresponsiveness depending on antigen load
por: Hadebe, Sabelo, et al.
Publicado: (2021)

NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity
por: Moecking, Jonas, et al.
Publicado: (2021)

The gut microbiome is a significant risk factor for future chronic lung disease
por: Liu, Yang, et al.
Publicado: (2023)

Endotypes identified by cluster analysis in asthmatics and non-asthmatics and their clinical characteristics at follow-up: the case-control EGEA study
por: Nadif, Rachel, et al.
Publicado: (2020)

Role of non-coding RNAs in maintaining primary airway smooth muscle cells
por: Perry, Mark M, et al.
Publicado: (2014)

Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling
por: Dilasser, Florian, et al.
Publicado: (2021)

Bronchial smooth muscle cell in asthma: where does it fit?
por: Hassoun, Dorian, et al.
Publicado: (2022)

uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium
por: Stewart, Ceri E, et al.
Publicado: (2011)

Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET clinical research collaboration
por: Bertels, Xander, et al.
Publicado: (2023)

Impending Airway Compromise due to Cystic Hygroma
por: Weiser, Giora, et al.
Publicado: (2011)

BET Bromodomains Regulate Transforming Growth Factor-β-induced Proliferation and Cytokine Release in Asthmatic Airway Smooth Muscle
por: Perry, Mark M., et al.
Publicado: (2015)

The adjuncts for endotracheal tube passage in simulated pediatric airways (AET‐SPA) study
por: Gan, Khang Hee, et al.
Publicado: (2022)

An oropharyngeal device for airway management of conscious and semiconscious patients: A randomized clinical trial
por: Freeman, Kalev, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3bshac9juf91gtocnkb99lhku1