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Sensitivity to image recurrence across eye-movement-like image transitions through local serial inhibition in the retina

Standard models of stimulus encoding in the retina postulate that image presentations activate neurons according to the increase of preferred contrast inside the receptive field. During natural vision, however, images do not arrive in isolation, but follow each other rapidly, separated by sudden gaz...

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Detalles Bibliográficos
Autores principales: Krishnamoorthy, Vidhyasankar, Weick, Michael, Gollisch, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338922/
https://www.ncbi.nlm.nih.gov/pubmed/28230526
http://dx.doi.org/10.7554/eLife.22431
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author Krishnamoorthy, Vidhyasankar
Weick, Michael
Gollisch, Tim
author_facet Krishnamoorthy, Vidhyasankar
Weick, Michael
Gollisch, Tim
author_sort Krishnamoorthy, Vidhyasankar
collection PubMed
description Standard models of stimulus encoding in the retina postulate that image presentations activate neurons according to the increase of preferred contrast inside the receptive field. During natural vision, however, images do not arrive in isolation, but follow each other rapidly, separated by sudden gaze shifts. We here report that, contrary to standard models, specific ganglion cells in mouse retina are suppressed after a rapid image transition by changes in visual patterns across the transition, but respond with a distinct spike burst when the same pattern reappears. This sensitivity to image recurrence depends on opposing effects of glycinergic and GABAergic inhibition and can be explained by a circuit of local serial inhibition. Rapid image transitions thus trigger a mode of operation that differs from the processing of simpler stimuli and allows the retina to tag particular image parts or to detect transition types that lead to recurring stimulus patterns. DOI: http://dx.doi.org/10.7554/eLife.22431.001
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spelling pubmed-53389222017-03-10 Sensitivity to image recurrence across eye-movement-like image transitions through local serial inhibition in the retina Krishnamoorthy, Vidhyasankar Weick, Michael Gollisch, Tim eLife Neuroscience Standard models of stimulus encoding in the retina postulate that image presentations activate neurons according to the increase of preferred contrast inside the receptive field. During natural vision, however, images do not arrive in isolation, but follow each other rapidly, separated by sudden gaze shifts. We here report that, contrary to standard models, specific ganglion cells in mouse retina are suppressed after a rapid image transition by changes in visual patterns across the transition, but respond with a distinct spike burst when the same pattern reappears. This sensitivity to image recurrence depends on opposing effects of glycinergic and GABAergic inhibition and can be explained by a circuit of local serial inhibition. Rapid image transitions thus trigger a mode of operation that differs from the processing of simpler stimuli and allows the retina to tag particular image parts or to detect transition types that lead to recurring stimulus patterns. DOI: http://dx.doi.org/10.7554/eLife.22431.001 eLife Sciences Publications, Ltd 2017-02-23 /pmc/articles/PMC5338922/ /pubmed/28230526 http://dx.doi.org/10.7554/eLife.22431 Text en © 2017, Krishnamoorthy et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Krishnamoorthy, Vidhyasankar
Weick, Michael
Gollisch, Tim
Sensitivity to image recurrence across eye-movement-like image transitions through local serial inhibition in the retina
title Sensitivity to image recurrence across eye-movement-like image transitions through local serial inhibition in the retina
title_full Sensitivity to image recurrence across eye-movement-like image transitions through local serial inhibition in the retina
title_fullStr Sensitivity to image recurrence across eye-movement-like image transitions through local serial inhibition in the retina
title_full_unstemmed Sensitivity to image recurrence across eye-movement-like image transitions through local serial inhibition in the retina
title_short Sensitivity to image recurrence across eye-movement-like image transitions through local serial inhibition in the retina
title_sort sensitivity to image recurrence across eye-movement-like image transitions through local serial inhibition in the retina
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338922/
https://www.ncbi.nlm.nih.gov/pubmed/28230526
http://dx.doi.org/10.7554/eLife.22431
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