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Topical phenytoin for the treatment of neuropathic pain

We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use of commercial topical analgesics is not widespread due to the facts that capsaicin creams or patches can give rise to side effects,...

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Detalles Bibliográficos
Autores principales: Kopsky, David J, Keppel Hesselink, Jan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338949/
https://www.ncbi.nlm.nih.gov/pubmed/28280381
http://dx.doi.org/10.2147/JPR.S129749
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author Kopsky, David J
Keppel Hesselink, Jan M
author_facet Kopsky, David J
Keppel Hesselink, Jan M
author_sort Kopsky, David J
collection PubMed
description We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use of commercial topical analgesics is not widespread due to the facts that capsaicin creams or patches can give rise to side effects, such as burning, and analgesic patches (e.g., lidocaine 5% patches) have complex handling, especially for geriatric patients. Only in a few countries, compounded creams based on tricyclic antidepressants or other (co-)analgesics are available. Such topical analgesic creams, however, are easy to administer and have a low propensity for inducing side effects. We, therefore, developed a new topical cream based on 5% and 10% phenytoin and described three successfully treated patients suffering from neuropathic pain. All patients were refractory to a number of other analgesics. In all patients, phenytoin cream was effective in reducing pain completely, without any side effects, and the tolerability was excellent. The onset of action of the phenytoin creams was within 30 minutes. Phenytoin cream might become a new treatment modality of the treatment of neuropathic pain.
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spelling pubmed-53389492017-03-09 Topical phenytoin for the treatment of neuropathic pain Kopsky, David J Keppel Hesselink, Jan M J Pain Res Case Series We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use of commercial topical analgesics is not widespread due to the facts that capsaicin creams or patches can give rise to side effects, such as burning, and analgesic patches (e.g., lidocaine 5% patches) have complex handling, especially for geriatric patients. Only in a few countries, compounded creams based on tricyclic antidepressants or other (co-)analgesics are available. Such topical analgesic creams, however, are easy to administer and have a low propensity for inducing side effects. We, therefore, developed a new topical cream based on 5% and 10% phenytoin and described three successfully treated patients suffering from neuropathic pain. All patients were refractory to a number of other analgesics. In all patients, phenytoin cream was effective in reducing pain completely, without any side effects, and the tolerability was excellent. The onset of action of the phenytoin creams was within 30 minutes. Phenytoin cream might become a new treatment modality of the treatment of neuropathic pain. Dove Medical Press 2017-02-27 /pmc/articles/PMC5338949/ /pubmed/28280381 http://dx.doi.org/10.2147/JPR.S129749 Text en © 2017 Kopsky and Keppel Hesselink. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Series
Kopsky, David J
Keppel Hesselink, Jan M
Topical phenytoin for the treatment of neuropathic pain
title Topical phenytoin for the treatment of neuropathic pain
title_full Topical phenytoin for the treatment of neuropathic pain
title_fullStr Topical phenytoin for the treatment of neuropathic pain
title_full_unstemmed Topical phenytoin for the treatment of neuropathic pain
title_short Topical phenytoin for the treatment of neuropathic pain
title_sort topical phenytoin for the treatment of neuropathic pain
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338949/
https://www.ncbi.nlm.nih.gov/pubmed/28280381
http://dx.doi.org/10.2147/JPR.S129749
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