Rational design of inducible CRISPR guide RNAs for de novo assembly of transcriptional programs

CRISPR-based transcription regulators (CRISPR-TRs) have transformed the current synthetic biology landscape by allowing specific activation or repression of any target gene. Here we report a modular and versatile framework enabling rapid implementation of inducible CRISPR-TRs in mammalian cells. Thi...

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Detalles Bibliográficos
Autores principales: Ferry, Quentin R. V., Lyutova, Radostina, Fulga, Tudor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339017/
https://www.ncbi.nlm.nih.gov/pubmed/28256578
http://dx.doi.org/10.1038/ncomms14633

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