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Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of the nervous system involving both upper and lower motor neurons. The patterns of structural and metabolic brain alterations are still unclear. Several studies using anatomical MRI yielded a number of discrepancies in...

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Autores principales: Buhour, M-S., Doidy, F., Mondou, A., Pélerin, A., Carluer, L., Eustache, F., Viader, F., Desgranges, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339262/
https://www.ncbi.nlm.nih.gov/pubmed/28266002
http://dx.doi.org/10.1186/s13550-017-0267-2
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author Buhour, M-S.
Doidy, F.
Mondou, A.
Pélerin, A.
Carluer, L.
Eustache, F.
Viader, F.
Desgranges, B.
author_facet Buhour, M-S.
Doidy, F.
Mondou, A.
Pélerin, A.
Carluer, L.
Eustache, F.
Viader, F.
Desgranges, B.
author_sort Buhour, M-S.
collection PubMed
description BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of the nervous system involving both upper and lower motor neurons. The patterns of structural and metabolic brain alterations are still unclear. Several studies using anatomical MRI yielded a number of discrepancies in their results, and a few PET studies investigated the effect of ALS on cerebral glucose metabolism. The aim of this study was threefold: to highlight the patterns of grey matter (GM) atrophy, hypometabolism and hypermetabolism in patients with ALS, then to understand the neurobehavioral significance of hypermetabolism and, finally, to investigate the regional differences between the morphologic and functional changes in ALS patients, using a specially designed voxel-based method. Thirty-seven patients with ALS and 37 age- and sex-matched healthy individuals underwent both structural MRI and (18)[F]-fluorodeoxyglucose (FDG) PET examinations. PET data were corrected for partial volume effects. Structural and metabolic abnormalities were examined in ALS patients compared with control subjects using two-sample t tests in statistical parametric mapping (SPM). Then, we extracted the metabolic values of clusters presenting hypermetabolism to correlate with selected cognitive scores. Finally, GM atrophy and hypometabolism patterns were directly compared with a one-paired t test in SPM. RESULTS: We found GM atrophy as well as hypometabolism in motor and extra motor regions and hypermetabolism in medial temporal lobe and cerebellum. We observed negative correlations between the metabolism of the right and left parahippocampal gyri and episodic memory and between the metabolism of right temporal pole and cognitive theory of mind. GM atrophy predominated in the temporal pole, left hippocampus and right thalamus, while hypometabolism predominated in a single cluster in the left frontal superior medial cortex. CONCLUSIONS: Our findings provide direct evidence of regional variations in the hierarchy and relationships between GM atrophy and hypometabolism in ALS. Moreover, the (18)FDG-PET investigation suggests that cerebral hypermetabolism is deleterious to cognitive function in ALS.
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spelling pubmed-53392622017-03-17 Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis Buhour, M-S. Doidy, F. Mondou, A. Pélerin, A. Carluer, L. Eustache, F. Viader, F. Desgranges, B. EJNMMI Res Original Research BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of the nervous system involving both upper and lower motor neurons. The patterns of structural and metabolic brain alterations are still unclear. Several studies using anatomical MRI yielded a number of discrepancies in their results, and a few PET studies investigated the effect of ALS on cerebral glucose metabolism. The aim of this study was threefold: to highlight the patterns of grey matter (GM) atrophy, hypometabolism and hypermetabolism in patients with ALS, then to understand the neurobehavioral significance of hypermetabolism and, finally, to investigate the regional differences between the morphologic and functional changes in ALS patients, using a specially designed voxel-based method. Thirty-seven patients with ALS and 37 age- and sex-matched healthy individuals underwent both structural MRI and (18)[F]-fluorodeoxyglucose (FDG) PET examinations. PET data were corrected for partial volume effects. Structural and metabolic abnormalities were examined in ALS patients compared with control subjects using two-sample t tests in statistical parametric mapping (SPM). Then, we extracted the metabolic values of clusters presenting hypermetabolism to correlate with selected cognitive scores. Finally, GM atrophy and hypometabolism patterns were directly compared with a one-paired t test in SPM. RESULTS: We found GM atrophy as well as hypometabolism in motor and extra motor regions and hypermetabolism in medial temporal lobe and cerebellum. We observed negative correlations between the metabolism of the right and left parahippocampal gyri and episodic memory and between the metabolism of right temporal pole and cognitive theory of mind. GM atrophy predominated in the temporal pole, left hippocampus and right thalamus, while hypometabolism predominated in a single cluster in the left frontal superior medial cortex. CONCLUSIONS: Our findings provide direct evidence of regional variations in the hierarchy and relationships between GM atrophy and hypometabolism in ALS. Moreover, the (18)FDG-PET investigation suggests that cerebral hypermetabolism is deleterious to cognitive function in ALS. Springer Berlin Heidelberg 2017-03-06 /pmc/articles/PMC5339262/ /pubmed/28266002 http://dx.doi.org/10.1186/s13550-017-0267-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Buhour, M-S.
Doidy, F.
Mondou, A.
Pélerin, A.
Carluer, L.
Eustache, F.
Viader, F.
Desgranges, B.
Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis
title Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis
title_full Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis
title_fullStr Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis
title_full_unstemmed Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis
title_short Voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis
title_sort voxel-based mapping of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339262/
https://www.ncbi.nlm.nih.gov/pubmed/28266002
http://dx.doi.org/10.1186/s13550-017-0267-2
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