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Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma

The fast proliferation of tumor cells develops faster than the vasculature, resulting, in most malignant tumors, in generation of hypoxic regions. Hypoxia renders solid tumors resistant to radiation and chemotherapeutics while providing opportunities for tumor-selective therapies targeting tumor hyp...

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Detalles Bibliográficos
Autores principales:	Shneor, D, Folberg, R, Pe'er, J, Honigman, A, Frenkel, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339434/ https://www.ncbi.nlm.nih.gov/pubmed/27934882 http://dx.doi.org/10.1038/cgt.2016.68

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