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Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival

BACKGROUND: It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs. METHODS: Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according...

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Detalles Bibliográficos
Autores principales: Rasti Ardakani, Mehdi, Al-Dam, Ahmed, Rashad, Ashkan, Shayesteh Moghadam, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society for Plastic Surgeons 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339610/
https://www.ncbi.nlm.nih.gov/pubmed/28289614
Descripción
Sumario:BACKGROUND: It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs. METHODS: Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation. RESULTS: Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (p<0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps. CONCLUSION: It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.