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Can Skin Allograft Occasionally Act as a Permanent Coverage in Deep Burns? A Pilot Study
BACKGROUND: Skin allograft is the gold standard of wound coverage in patients with extensive burns; however, it is considered as a temporary wound coverage and rejection of the skin allograft is considered inevitable. In our study, skin allograft as a permanent coverage in deep burns is evaluated. M...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Society for Plastic Surgeons
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339616/ https://www.ncbi.nlm.nih.gov/pubmed/28289620 |
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author | Rezaei, Ezzatollah Beiraghi-Toosi, Arash Ahmadabadi, Ali Tavousi, Seyed Hassan Alipour Tabrizi, Arash Fotuhi, Kazem Jabbari Nooghabi, Mehdi Manafi, Amir Ahmadi Moghadam, Shokoofeh |
author_facet | Rezaei, Ezzatollah Beiraghi-Toosi, Arash Ahmadabadi, Ali Tavousi, Seyed Hassan Alipour Tabrizi, Arash Fotuhi, Kazem Jabbari Nooghabi, Mehdi Manafi, Amir Ahmadi Moghadam, Shokoofeh |
author_sort | Rezaei, Ezzatollah |
collection | PubMed |
description | BACKGROUND: Skin allograft is the gold standard of wound coverage in patients with extensive burns; however, it is considered as a temporary wound coverage and rejection of the skin allograft is considered inevitable. In our study, skin allograft as a permanent coverage in deep burns is evaluated. METHODS: Skin allograft survival was assessed in 38 patients from March 2009 to March 2014, retrospectively. Because of the lack of tissue specimen from the skin donors, patients with long skin allograft survival in whom the gender of donor and recipient of allograft was the same were excluded. Seven cases with skin allograft longevity and opposite gender in donor and recipient were finally enrolled. A polymerase chain reaction (PCR) test on the biopsy specimen from recipients and donors were undertaken. RESULTS: PCR on the biopsy specimen from recipients confirmed those specimens belong to the donors. All patients received allograft from the opposite sex. Two (28.57%) patients received allograft from their first-degree blood relatives, and in one (14.29%) case, the allograft was harvested from an alive individual with no blood relation. The rest were harvested from multiorgan donors. In eight months of follow up, no clinical evidence of graft rejection was noted. CONCLUSION: Long term persistence of skin allograft in patients is worthy of more attention. Further studies An increase in knowledge of factors influencing this longevity could realize the dream of burn surgeons to achieve a permanent coverage other than autograft for major burn patients. |
format | Online Article Text |
id | pubmed-5339616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Iranian Society for Plastic Surgeons |
record_format | MEDLINE/PubMed |
spelling | pubmed-53396162017-03-13 Can Skin Allograft Occasionally Act as a Permanent Coverage in Deep Burns? A Pilot Study Rezaei, Ezzatollah Beiraghi-Toosi, Arash Ahmadabadi, Ali Tavousi, Seyed Hassan Alipour Tabrizi, Arash Fotuhi, Kazem Jabbari Nooghabi, Mehdi Manafi, Amir Ahmadi Moghadam, Shokoofeh World J Plast Surg Short Communication BACKGROUND: Skin allograft is the gold standard of wound coverage in patients with extensive burns; however, it is considered as a temporary wound coverage and rejection of the skin allograft is considered inevitable. In our study, skin allograft as a permanent coverage in deep burns is evaluated. METHODS: Skin allograft survival was assessed in 38 patients from March 2009 to March 2014, retrospectively. Because of the lack of tissue specimen from the skin donors, patients with long skin allograft survival in whom the gender of donor and recipient of allograft was the same were excluded. Seven cases with skin allograft longevity and opposite gender in donor and recipient were finally enrolled. A polymerase chain reaction (PCR) test on the biopsy specimen from recipients and donors were undertaken. RESULTS: PCR on the biopsy specimen from recipients confirmed those specimens belong to the donors. All patients received allograft from the opposite sex. Two (28.57%) patients received allograft from their first-degree blood relatives, and in one (14.29%) case, the allograft was harvested from an alive individual with no blood relation. The rest were harvested from multiorgan donors. In eight months of follow up, no clinical evidence of graft rejection was noted. CONCLUSION: Long term persistence of skin allograft in patients is worthy of more attention. Further studies An increase in knowledge of factors influencing this longevity could realize the dream of burn surgeons to achieve a permanent coverage other than autograft for major burn patients. Iranian Society for Plastic Surgeons 2017-01 /pmc/articles/PMC5339616/ /pubmed/28289620 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Rezaei, Ezzatollah Beiraghi-Toosi, Arash Ahmadabadi, Ali Tavousi, Seyed Hassan Alipour Tabrizi, Arash Fotuhi, Kazem Jabbari Nooghabi, Mehdi Manafi, Amir Ahmadi Moghadam, Shokoofeh Can Skin Allograft Occasionally Act as a Permanent Coverage in Deep Burns? A Pilot Study |
title | Can Skin Allograft Occasionally Act as a Permanent Coverage in Deep Burns? A Pilot Study |
title_full | Can Skin Allograft Occasionally Act as a Permanent Coverage in Deep Burns? A Pilot Study |
title_fullStr | Can Skin Allograft Occasionally Act as a Permanent Coverage in Deep Burns? A Pilot Study |
title_full_unstemmed | Can Skin Allograft Occasionally Act as a Permanent Coverage in Deep Burns? A Pilot Study |
title_short | Can Skin Allograft Occasionally Act as a Permanent Coverage in Deep Burns? A Pilot Study |
title_sort | can skin allograft occasionally act as a permanent coverage in deep burns? a pilot study |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339616/ https://www.ncbi.nlm.nih.gov/pubmed/28289620 |
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