Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome

Genetic alterations disrupting the transcription factor IKZF1 (encoding IKAROS) are associated with poor outcome in B lineage acute lymphoblastic leukemia (B-ALL) and occur in >70% of the high-risk BCR-ABL1(+) (Ph(+)) and Ph-like disease subtypes. To examine IKAROS function in this context, we ha...

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Detalles Bibliográficos
Autores principales: Witkowski, Matthew T., Hu, Yifang, Roberts, Kathryn G., Boer, Judith M., McKenzie, Mark D., Liu, Grace J., Le Grice, Oliver D., Tremblay, Cedric S., Ghisi, Margherita, Willson, Tracy A., Horstmann, Martin A., Aifantis, Iannis, Cimmino, Luisa, Frietze, Seth, den Boer, Monique L., Mullighan, Charles G., Smyth, Gordon K., Dickins, Ross A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339666/
https://www.ncbi.nlm.nih.gov/pubmed/28190000
http://dx.doi.org/10.1084/jem.20160048

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