Cargando…

Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity

The regulatory T cell (T reg cell) T cell receptor (TCR) repertoire is highly diverse and skewed toward recognition of self-antigens. TCR expression by T reg cells is continuously required for maintenance of immune tolerance and for a major part of their characteristic gene expression signature; how...

Descripción completa

Detalles Bibliográficos
Autores principales:	Levine, Andrew G., Hemmers, Saskia, Baptista, Antonio P., Schizas, Michail, Faire, Mehlika B., Moltedo, Bruno, Konopacki, Catherine, Schmidt-Supprian, Marc, Germain, Ronald N., Treuting, Piper M., Rudensky, Alexander Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339675/ https://www.ncbi.nlm.nih.gov/pubmed/28130403 http://dx.doi.org/10.1084/jem.20161318

Ejemplares similares

Stability and function of regulatory T cells expressing the transcription factor T-bet
por: Levine, Andrew G., et al.
Publicado: (2017)

Regulatory T Cell Ablation Causes Acute T Cell Lymphopenia
por: Moltedo, Bruno, et al.
Publicado: (2014)

T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation
por: Hemmers, Saskia, et al.
Publicado: (2020)

A mechanism for expansion of regulatory T cell repertoire and its role in self tolerance
por: Feng, Yongqiang, et al.
Publicado: (2015)

IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus
por: Hemmers, Saskia, et al.
Publicado: (2019)

Regulatory T Cells Function in Established Systemic Inflammation and Reverse Fatal Autoimmunity
por: Hu, Wei, et al.
Publicado: (2021)

Runx-CBFβ complexes control Foxp3 expression in regulatory T cells
por: Rudra, Dipayan, et al.
Publicado: (2009)

TCR signals fuel T(reg) cells
por: Drees, Christoph, et al.
Publicado: (2015)

CD49b defines functionally mature Treg cells that survey skin and vascular tissues
por: Fan, Xiying, et al.
Publicado: (2018)

Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease
por: Sather, Blythe D., et al.
Publicado: (2007)

IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
por: Gasteiger, Georg, et al.
Publicado: (2013)

Autoimmune TCR structure
por: LeBrasseur, Nicole
Publicado: (2005)

IL-2–dependent adaptive control of NK cell homeostasis
por: Gasteiger, Georg, et al.
Publicado: (2013)

A nonimmune function of T cells in promoting lung tumor progression
por: Green, Jesse A., et al.
Publicado: (2017)

NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology
por: Vahl, J. Christoph, et al.
Publicado: (2013)

Autoimmune susceptibility imposed by public TCRβ chains
por: Zhao, Yunqian, et al.
Publicado: (2016)

Continuous requirement for the T cell receptor for regulatory T cell function
por: Levine, Andrew G, et al.
Publicado: (2014)

NF-κB in control of regulatory T cell development, identity, and function
por: Hövelmeyer, Nadine, et al.
Publicado: (2022)

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells
por: Fleskens, Veerle, et al.
Publicado: (2019)

Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy
por: Castro-Sanchez, Patricia, et al.
Publicado: (2020)

Practical pathology of aging mice
por: Pettan-Brewer, Christina, et al.
Publicado: (2011)

Impact of the TCR Signal on Regulatory T Cell Homeostasis, Function, and Trafficking
por: Kim, Joong Kyu, et al.
Publicado: (2009)

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis
por: Ashouri, Judith F., et al.
Publicado: (2019)

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
por: Chong, Mark M.W., et al.
Publicado: (2008)

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
por: Chong, Mark M.W., et al.
Publicado: (2008)

T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice
Publicado: (1994)

T follicular helper and T follicular regulatory cells have different TCR specificity
por: Maceiras, Ana Raquel, et al.
Publicado: (2017)

Regulatory T cells and co‐evolution of allele‐specific MHC recognition by the TCR
por: Steele, Edward J., et al.
Publicado: (2019)

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
por: Paterson, Alison M., et al.
Publicado: (2015)

Pathology is a critical aspect of preclinical aging studies
por: Ladiges, Warren, et al.
Publicado: (2013)

Rodentia
por: Delaney, Martha A., et al.
Publicado: (2018)

Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease
por: Hwang, SuJin, et al.
Publicado: (2012)

The Autoimmunity Risk Variant LYP-W620 Cooperates with CSK in the Regulation of TCR Signaling
por: de la Puerta, María Luisa, et al.
Publicado: (2013)

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004)

Characterization of Dextran Sodium Sulfate-Induced Inflammation and Colonic Tumorigenesis in Smad3 (−/−) Mice with Dysregulated TGFβ
por: Seamons, Audrey, et al.
Publicado: (2013)

TGF-β Signalling Is Required for CD4(+) T Cell Homeostasis But Dispensable for Regulatory T Cell Function
por: Śledzińska, Anna, et al.
Publicado: (2013)

The Efficiency of CD4 Recruitment to Ligand-engaged TCR Controls the Agonist/Partial Agonist Properties of Peptide–MHC Molecule Ligands
por: Madrenas, Joaquín, et al.
Publicado: (1997)

Bacillus anthracis Lethal Toxin Disrupts TCR Signaling in CD1d-Restricted NKT Cells Leading to Functional Anergy
por: Joshi, Sunil K., et al.
Publicado: (2009)

Loss of Roquin induces early death and immune deregulation but not autoimmunity
por: Bertossi, Arianna, et al.
Publicado: (2011)

Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs
por: Attridge, Kesley, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4c50705s14467rvpeipq5pp1i7