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Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography

Nonlinear sampling of the interferograms in wavenumber (k) space degrades the depth-dependent signal sensitivity in conventional spectral domain optical coherence tomography (SD-OCT). Here we report a linear-in-wavenumber (k-space) spectrometer for an ultra-broad bandwidth (760 nm–920 nm) SD-OCT, wh...

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Autores principales: Lan, Gongpu, Li, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339709/
https://www.ncbi.nlm.nih.gov/pubmed/28266502
http://dx.doi.org/10.1038/srep42353
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author Lan, Gongpu
Li, Guoqiang
author_facet Lan, Gongpu
Li, Guoqiang
author_sort Lan, Gongpu
collection PubMed
description Nonlinear sampling of the interferograms in wavenumber (k) space degrades the depth-dependent signal sensitivity in conventional spectral domain optical coherence tomography (SD-OCT). Here we report a linear-in-wavenumber (k-space) spectrometer for an ultra-broad bandwidth (760 nm–920 nm) SD-OCT, whereby a combination of a grating and a prism serves as the dispersion group. Quantitative ray tracing is applied to optimize the linearity and minimize the optical path differences for the dispersed wavenumbers. Zemax simulation is used to fit the point spread functions to the rectangular shape of the pixels of the line-scan camera and to improve the pixel sampling rates. An experimental SD-OCT is built to test and compare the performance of the k-space spectrometer with that of a conventional one. Design results demonstrate that this k-space spectrometer can reduce the nonlinearity error in k-space from 14.86% to 0.47% (by approximately 30 times) compared to the conventional spectrometer. The 95% confidence interval for RMS diameters is 5.48 ± 1.76 μm—significantly smaller than both the pixel size (14 μm × 28 μm) and the Airy disc (25.82 μm in diameter, calculated at the wavenumber of 7.548 μm(−1)). Test results demonstrate that the fall-off curve from the k-space spectrometer exhibits much less decay (maximum as −5.20 dB) than the conventional spectrometer (maximum as –16.84 dB) over the whole imaging depth (2.2 mm).
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spelling pubmed-53397092017-03-10 Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography Lan, Gongpu Li, Guoqiang Sci Rep Article Nonlinear sampling of the interferograms in wavenumber (k) space degrades the depth-dependent signal sensitivity in conventional spectral domain optical coherence tomography (SD-OCT). Here we report a linear-in-wavenumber (k-space) spectrometer for an ultra-broad bandwidth (760 nm–920 nm) SD-OCT, whereby a combination of a grating and a prism serves as the dispersion group. Quantitative ray tracing is applied to optimize the linearity and minimize the optical path differences for the dispersed wavenumbers. Zemax simulation is used to fit the point spread functions to the rectangular shape of the pixels of the line-scan camera and to improve the pixel sampling rates. An experimental SD-OCT is built to test and compare the performance of the k-space spectrometer with that of a conventional one. Design results demonstrate that this k-space spectrometer can reduce the nonlinearity error in k-space from 14.86% to 0.47% (by approximately 30 times) compared to the conventional spectrometer. The 95% confidence interval for RMS diameters is 5.48 ± 1.76 μm—significantly smaller than both the pixel size (14 μm × 28 μm) and the Airy disc (25.82 μm in diameter, calculated at the wavenumber of 7.548 μm(−1)). Test results demonstrate that the fall-off curve from the k-space spectrometer exhibits much less decay (maximum as −5.20 dB) than the conventional spectrometer (maximum as –16.84 dB) over the whole imaging depth (2.2 mm). Nature Publishing Group 2017-03-07 /pmc/articles/PMC5339709/ /pubmed/28266502 http://dx.doi.org/10.1038/srep42353 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lan, Gongpu
Li, Guoqiang
Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography
title Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography
title_full Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography
title_fullStr Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography
title_full_unstemmed Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography
title_short Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography
title_sort design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339709/
https://www.ncbi.nlm.nih.gov/pubmed/28266502
http://dx.doi.org/10.1038/srep42353
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AT liguoqiang designofakspacespectrometerforultrabroadwavebandspectraldomainopticalcoherencetomography