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Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography
Nonlinear sampling of the interferograms in wavenumber (k) space degrades the depth-dependent signal sensitivity in conventional spectral domain optical coherence tomography (SD-OCT). Here we report a linear-in-wavenumber (k-space) spectrometer for an ultra-broad bandwidth (760 nm–920 nm) SD-OCT, wh...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339709/ https://www.ncbi.nlm.nih.gov/pubmed/28266502 http://dx.doi.org/10.1038/srep42353 |
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author | Lan, Gongpu Li, Guoqiang |
author_facet | Lan, Gongpu Li, Guoqiang |
author_sort | Lan, Gongpu |
collection | PubMed |
description | Nonlinear sampling of the interferograms in wavenumber (k) space degrades the depth-dependent signal sensitivity in conventional spectral domain optical coherence tomography (SD-OCT). Here we report a linear-in-wavenumber (k-space) spectrometer for an ultra-broad bandwidth (760 nm–920 nm) SD-OCT, whereby a combination of a grating and a prism serves as the dispersion group. Quantitative ray tracing is applied to optimize the linearity and minimize the optical path differences for the dispersed wavenumbers. Zemax simulation is used to fit the point spread functions to the rectangular shape of the pixels of the line-scan camera and to improve the pixel sampling rates. An experimental SD-OCT is built to test and compare the performance of the k-space spectrometer with that of a conventional one. Design results demonstrate that this k-space spectrometer can reduce the nonlinearity error in k-space from 14.86% to 0.47% (by approximately 30 times) compared to the conventional spectrometer. The 95% confidence interval for RMS diameters is 5.48 ± 1.76 μm—significantly smaller than both the pixel size (14 μm × 28 μm) and the Airy disc (25.82 μm in diameter, calculated at the wavenumber of 7.548 μm(−1)). Test results demonstrate that the fall-off curve from the k-space spectrometer exhibits much less decay (maximum as −5.20 dB) than the conventional spectrometer (maximum as –16.84 dB) over the whole imaging depth (2.2 mm). |
format | Online Article Text |
id | pubmed-5339709 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53397092017-03-10 Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography Lan, Gongpu Li, Guoqiang Sci Rep Article Nonlinear sampling of the interferograms in wavenumber (k) space degrades the depth-dependent signal sensitivity in conventional spectral domain optical coherence tomography (SD-OCT). Here we report a linear-in-wavenumber (k-space) spectrometer for an ultra-broad bandwidth (760 nm–920 nm) SD-OCT, whereby a combination of a grating and a prism serves as the dispersion group. Quantitative ray tracing is applied to optimize the linearity and minimize the optical path differences for the dispersed wavenumbers. Zemax simulation is used to fit the point spread functions to the rectangular shape of the pixels of the line-scan camera and to improve the pixel sampling rates. An experimental SD-OCT is built to test and compare the performance of the k-space spectrometer with that of a conventional one. Design results demonstrate that this k-space spectrometer can reduce the nonlinearity error in k-space from 14.86% to 0.47% (by approximately 30 times) compared to the conventional spectrometer. The 95% confidence interval for RMS diameters is 5.48 ± 1.76 μm—significantly smaller than both the pixel size (14 μm × 28 μm) and the Airy disc (25.82 μm in diameter, calculated at the wavenumber of 7.548 μm(−1)). Test results demonstrate that the fall-off curve from the k-space spectrometer exhibits much less decay (maximum as −5.20 dB) than the conventional spectrometer (maximum as –16.84 dB) over the whole imaging depth (2.2 mm). Nature Publishing Group 2017-03-07 /pmc/articles/PMC5339709/ /pubmed/28266502 http://dx.doi.org/10.1038/srep42353 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Lan, Gongpu Li, Guoqiang Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography |
title | Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography |
title_full | Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography |
title_fullStr | Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography |
title_full_unstemmed | Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography |
title_short | Design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography |
title_sort | design of a k-space spectrometer for ultra-broad waveband spectral domain optical coherence tomography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339709/ https://www.ncbi.nlm.nih.gov/pubmed/28266502 http://dx.doi.org/10.1038/srep42353 |
work_keys_str_mv | AT langongpu designofakspacespectrometerforultrabroadwavebandspectraldomainopticalcoherencetomography AT liguoqiang designofakspacespectrometerforultrabroadwavebandspectraldomainopticalcoherencetomography |