Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding

Werner syndrome is caused by mutations in the WRN gene encoding WRN helicase. A knowledge of WRN helicase’s DNA unwinding mechanism in vitro is helpful for predicting its behaviors in vivo, and then understanding their biological functions. In the present study, for deeply understanding the DNA unwi...

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Detalles Bibliográficos
Autores principales: Wu, Wen-Qiang, Hou, Xi-Miao, Zhang, Bo, Fossé, Philippe, René, Brigitte, Mauffret, Olivier, Li, Ming, Dou, Shuo-Xing, Xi, Xu-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339710/
https://www.ncbi.nlm.nih.gov/pubmed/28266653
http://dx.doi.org/10.1038/srep43954

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