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Unique Contributions of an Arginine Side Chain to Ligand Recognition in a Glutamate-gated Chloride Channel

Glutamate recognition by neurotransmitter receptors often relies on Arg residues in the binding site, leading to the assumption that charge-charge interactions underlie ligand recognition. However, assessing the precise chemical contribution of Arg side chains to protein function and pharmacology ha...

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Detalles Bibliográficos
Autores principales:	Lynagh, Timothy, Komnatnyy, Vitaly V., Pless, Stephan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339774/ https://www.ncbi.nlm.nih.gov/pubmed/28096462 http://dx.doi.org/10.1074/jbc.M116.772939

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