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Superior Pre-Osteoblast Cell Response of Etched Ultrafine-Grained Titanium with a Controlled Crystallographic Orientation
Ultrafine-grained (UFG) Ti for improved mechanical performance as well as its surface modification enhancing biofunctions has attracted much attention in medical industries. Most of the studies on the surface etching of metallic biomaterials have focused on surface topography and wettability but not...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339782/ https://www.ncbi.nlm.nih.gov/pubmed/28266643 http://dx.doi.org/10.1038/srep44213 |
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author | Baek, Seung Mi Shin, Myeong Hwan Moon, Jongun Jung, Ho Sang Lee, See Am Hwang, WoonBong Yeom, Jong Taek Hahn, Sei Kwang Kim, Hyoung Seop |
author_facet | Baek, Seung Mi Shin, Myeong Hwan Moon, Jongun Jung, Ho Sang Lee, See Am Hwang, WoonBong Yeom, Jong Taek Hahn, Sei Kwang Kim, Hyoung Seop |
author_sort | Baek, Seung Mi |
collection | PubMed |
description | Ultrafine-grained (UFG) Ti for improved mechanical performance as well as its surface modification enhancing biofunctions has attracted much attention in medical industries. Most of the studies on the surface etching of metallic biomaterials have focused on surface topography and wettability but not crystallographic orientation, i.e., texture, which influences the chemical as well as the physical properties. In this paper, the influences of texture and grain size on roughness, wettability, and pre-osteoblast cell response were investigated in vitro after HF etching treatment. The surface characteristics and cell behaviors of ultrafine, fine, and coarse-grained Ti were examined after the HF etching. The surface roughness during the etching treatment was significantly increased as the orientation angle from the basal pole was increased. The cell adhesion tendency of the rough surface was promoted. The UFG Ti substrate exhibited a higher texture energy state, rougher surface, enhanced hydrophilic wettability, and better cell adhesion and proliferation behaviors after etching than those of the coarse- and fine-grained Ti substrates. These results provide a new route for enhancing both mechanical and biological performances using etching after grain refinement of Ti. |
format | Online Article Text |
id | pubmed-5339782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53397822017-03-10 Superior Pre-Osteoblast Cell Response of Etched Ultrafine-Grained Titanium with a Controlled Crystallographic Orientation Baek, Seung Mi Shin, Myeong Hwan Moon, Jongun Jung, Ho Sang Lee, See Am Hwang, WoonBong Yeom, Jong Taek Hahn, Sei Kwang Kim, Hyoung Seop Sci Rep Article Ultrafine-grained (UFG) Ti for improved mechanical performance as well as its surface modification enhancing biofunctions has attracted much attention in medical industries. Most of the studies on the surface etching of metallic biomaterials have focused on surface topography and wettability but not crystallographic orientation, i.e., texture, which influences the chemical as well as the physical properties. In this paper, the influences of texture and grain size on roughness, wettability, and pre-osteoblast cell response were investigated in vitro after HF etching treatment. The surface characteristics and cell behaviors of ultrafine, fine, and coarse-grained Ti were examined after the HF etching. The surface roughness during the etching treatment was significantly increased as the orientation angle from the basal pole was increased. The cell adhesion tendency of the rough surface was promoted. The UFG Ti substrate exhibited a higher texture energy state, rougher surface, enhanced hydrophilic wettability, and better cell adhesion and proliferation behaviors after etching than those of the coarse- and fine-grained Ti substrates. These results provide a new route for enhancing both mechanical and biological performances using etching after grain refinement of Ti. Nature Publishing Group 2017-03-07 /pmc/articles/PMC5339782/ /pubmed/28266643 http://dx.doi.org/10.1038/srep44213 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Baek, Seung Mi Shin, Myeong Hwan Moon, Jongun Jung, Ho Sang Lee, See Am Hwang, WoonBong Yeom, Jong Taek Hahn, Sei Kwang Kim, Hyoung Seop Superior Pre-Osteoblast Cell Response of Etched Ultrafine-Grained Titanium with a Controlled Crystallographic Orientation |
title | Superior Pre-Osteoblast Cell Response of Etched Ultrafine-Grained Titanium with a Controlled Crystallographic Orientation |
title_full | Superior Pre-Osteoblast Cell Response of Etched Ultrafine-Grained Titanium with a Controlled Crystallographic Orientation |
title_fullStr | Superior Pre-Osteoblast Cell Response of Etched Ultrafine-Grained Titanium with a Controlled Crystallographic Orientation |
title_full_unstemmed | Superior Pre-Osteoblast Cell Response of Etched Ultrafine-Grained Titanium with a Controlled Crystallographic Orientation |
title_short | Superior Pre-Osteoblast Cell Response of Etched Ultrafine-Grained Titanium with a Controlled Crystallographic Orientation |
title_sort | superior pre-osteoblast cell response of etched ultrafine-grained titanium with a controlled crystallographic orientation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339782/ https://www.ncbi.nlm.nih.gov/pubmed/28266643 http://dx.doi.org/10.1038/srep44213 |
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