ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation

Selective treatments for myocardial infarction (MI) induced cardiac fibrosis are lacking. In this study, we focus on the therapeutic potential of a synthetic cardio-protective agent named ZYZ-168 towards MI-induced cardiac fibrosis and try to reveal the underlying mechanism. ZYZ-168 was administered...

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Detalles Bibliográficos
Autores principales: Luo, Shanshan, Hieu, Tran Ba, Ma, Fenfen, Yu, Ying, Cao, Zhonglian, Wang, Minjun, Wu, Weijun, Mao, Yicheng, Rose, Peter, Law, Betty Yuen-Kwan, Zhu, Yi Zhun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339863/
https://www.ncbi.nlm.nih.gov/pubmed/28266583
http://dx.doi.org/10.1038/srep43242

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