Improved Bioavailability and Antitumor Effect of Docetaxel by TPGS Modified Proniosomes: In Vitro and In Vivo Evaluations

A novel oral drug delivery system, TPGS modified docetaxel proniosomes (DTX-TPGS-PNs), was designed to enhance the oral bioavailability and antitumor efficiency of the poorly water-soluble drug docetaxel. DTX-TPGS-PN niosomes were 93 ± 6.5 nm in size, −18.53 ± 1.65 mV in zeta potential and exhibited...

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Detalles Bibliográficos
Autores principales: Liu, Helong, Tu, Liangxing, Zhou, Yongxin, Dang, Zefang, Wang, Luting, Du, Junfeng, Feng, Jianfang, Hu, Kaili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339906/
https://www.ncbi.nlm.nih.gov/pubmed/28266539
http://dx.doi.org/10.1038/srep43372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339906/
https://www.ncbi.nlm.nih.gov/pubmed/28266539
http://dx.doi.org/10.1038/srep43372

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