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Molecular mechanism of G(1) arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells

BACKGROUND: Overexpression of cyclin D1 dependent kinases 4 and 6 (CDK4/6) is a common feature of many human cancers including leukemia. LEE011 is a novel inhibitor of both CDK4 and 6. To date, the molecular function of LEE011 in leukemia remains unclear. METHODS: Leukemia cell growth and apoptosis...

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Detalles Bibliográficos
Autores principales:	Tao, Yan-Fang, Wang, Na-Na, Xu, Li-Xiao, Li, Zhi-Heng, Li, Xiao-Lu, Xu, Yun-Yun, Fang, Fang, Li, Mei, Qian, Guang-Hui, Li, Yan-Hong, Li, Yi-Ping, Wu, Yi, Ren, Jun-Li, Du, Wei-Wei, Lu, Jun, Feng, Xing, Wang, Jian, He, Wei-Qi, Hu, Shao-Yan, Pan, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340031/ https://www.ncbi.nlm.nih.gov/pubmed/28286417 http://dx.doi.org/10.1186/s12935-017-0405-y

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