Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming

Multiple Myeloma (MM) is a B-cell malignancy characterized by the accumulation of clonal plasma cells in the bone marrow, with drug resistance being a major cause of therapeutic failure. We established a carfilzomib-resistant derivative of the LP-1 MM cell line (LP-1/Cfz) and found that the transcri...

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Detalles Bibliográficos
Autores principales: Riz, Irene, Hawley, Teresa S., Marsal, Jeffrey W., Hawley, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340085/
https://www.ncbi.nlm.nih.gov/pubmed/27626179
http://dx.doi.org/10.18632/oncotarget.11960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340085/
https://www.ncbi.nlm.nih.gov/pubmed/27626179
http://dx.doi.org/10.18632/oncotarget.11960

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