Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras

We previously demonstrated activation of the mitogen-activated protein kinase (MAPK) pathway in a series of romidepsin-selected T-cell lymphoma cell lines as a mechanism of resistance to the histone deacetylase inhibitor (HDI), romidepsin. As Ras mutation leads to activation of both the MAPK and the...

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Detalles Bibliográficos
Autores principales: Bahr, Julian C., Robey, Robert W., Luchenko, Victoria, Basseville, Agnes, Chakraborty, Arup R., Kozlowski, Hanna, Pauly, Gary T., Patel, Paresma, Schneider, Joel P., Gottesman, Michael M., Bates, Susan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340114/
https://www.ncbi.nlm.nih.gov/pubmed/27634878
http://dx.doi.org/10.18632/oncotarget.12001

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