Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer

Despite ubiquitous activation in human cancer, essential downstream effector pathways of the MYC transcription factor have been difficult to define and target. Using a structure/function-based approach, we identified the mitochondrial RNA polymerase (POLRMT) locus as a critical downstream target of...

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Detalles Bibliográficos
Autores principales: Oran, Amanda R., Adams, Clare M., Zhang, Xiao-yong, Gennaro, Victoria J., Pfeiffer, Harla K., Mellert, Hestia S., Seidel, Hans E., Mascioli, Kirsten, Kaplan, Jordan, Gaballa, Mahmoud R., Shen, Chen, Rigoutsos, Isidore, King, Michael P., Cotney, Justin L., Arnold, Jamie J., Sharma, Suresh D., Martinez, Ubaldo E., Vakoc, Christopher R., Chodosh, Lewis A., Thompson, James E., Bradner, James E., Cameron, Craig E., Shadel, Gerald S., Eischen, Christine M., McMahon, Steven B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340124/
https://www.ncbi.nlm.nih.gov/pubmed/27590350
http://dx.doi.org/10.18632/oncotarget.11718

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