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Clomiphene citrate versus letrozole with gonadotropins in intrauterine insemination cycles: A randomized trial
BACKGROUND: Clomiphene citrate is one of the effective drugs for infertility treatment due to oligo-ovulation or anovulation. Intrauterine insemination (IUI) is one of more adherent methods for treatment of infertile cases which is followed by controlled ovarian hyperstimulation (COH). OBJECTIVE: th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research and Clinical Center for Infertility
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340139/ https://www.ncbi.nlm.nih.gov/pubmed/28280800 |
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author | Pourali, Leila Ayati, Sedigheh Tavakolizadeh, Shirin Soleimani, Hourieh Teimouri Sani, Fatemeh |
author_facet | Pourali, Leila Ayati, Sedigheh Tavakolizadeh, Shirin Soleimani, Hourieh Teimouri Sani, Fatemeh |
author_sort | Pourali, Leila |
collection | PubMed |
description | BACKGROUND: Clomiphene citrate is one of the effective drugs for infertility treatment due to oligo-ovulation or anovulation. Intrauterine insemination (IUI) is one of more adherent methods for treatment of infertile cases which is followed by controlled ovarian hyperstimulation (COH). OBJECTIVE: the aim of this study was to evaluate Clomiphene citrate versus letrozole with gonadotropins in IUI cycles. MATERIALS AND METHODS: In this prospective randomized trial, 180 infertile women who were referred to Milad Hospital were selected. The first group received 5 mg/day letrozole on day 3-7 of menstrual cycle. The second group received 100 mg/day Clomiphene in the same way as letrozole. In both groups, human menopausal gonadotropin was administered every day starting on day between 6-8 of cycle. Ovulation was triggered with urinary Human Chorionic Gonadotropin (5000 IU) when have two follicles of ≥16 mm. IUI was performed 36 hr later. RESULTS: The number of matured follicles, cycle cancellation, and abortion were the same in both groups. Endometrial thickness was higher at the time of human menopausal gonadotropin administration in letrozole group. Chemical and clinical pregnancy rates were much higher in letrozole group. Ovarian hyperstimulation was significantly higher in clomiphene group. CONCLUSION: Letrozole appears to be a good alternative to clomiphene citrate with fewer side effects. |
format | Online Article Text |
id | pubmed-5340139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Research and Clinical Center for Infertility |
record_format | MEDLINE/PubMed |
spelling | pubmed-53401392017-03-09 Clomiphene citrate versus letrozole with gonadotropins in intrauterine insemination cycles: A randomized trial Pourali, Leila Ayati, Sedigheh Tavakolizadeh, Shirin Soleimani, Hourieh Teimouri Sani, Fatemeh Int J Reprod Biomed Original Article BACKGROUND: Clomiphene citrate is one of the effective drugs for infertility treatment due to oligo-ovulation or anovulation. Intrauterine insemination (IUI) is one of more adherent methods for treatment of infertile cases which is followed by controlled ovarian hyperstimulation (COH). OBJECTIVE: the aim of this study was to evaluate Clomiphene citrate versus letrozole with gonadotropins in IUI cycles. MATERIALS AND METHODS: In this prospective randomized trial, 180 infertile women who were referred to Milad Hospital were selected. The first group received 5 mg/day letrozole on day 3-7 of menstrual cycle. The second group received 100 mg/day Clomiphene in the same way as letrozole. In both groups, human menopausal gonadotropin was administered every day starting on day between 6-8 of cycle. Ovulation was triggered with urinary Human Chorionic Gonadotropin (5000 IU) when have two follicles of ≥16 mm. IUI was performed 36 hr later. RESULTS: The number of matured follicles, cycle cancellation, and abortion were the same in both groups. Endometrial thickness was higher at the time of human menopausal gonadotropin administration in letrozole group. Chemical and clinical pregnancy rates were much higher in letrozole group. Ovarian hyperstimulation was significantly higher in clomiphene group. CONCLUSION: Letrozole appears to be a good alternative to clomiphene citrate with fewer side effects. Research and Clinical Center for Infertility 2017-01 /pmc/articles/PMC5340139/ /pubmed/28280800 Text en http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Pourali, Leila Ayati, Sedigheh Tavakolizadeh, Shirin Soleimani, Hourieh Teimouri Sani, Fatemeh Clomiphene citrate versus letrozole with gonadotropins in intrauterine insemination cycles: A randomized trial |
title | Clomiphene citrate versus letrozole with gonadotropins in intrauterine insemination cycles: A randomized trial |
title_full | Clomiphene citrate versus letrozole with gonadotropins in intrauterine insemination cycles: A randomized trial |
title_fullStr | Clomiphene citrate versus letrozole with gonadotropins in intrauterine insemination cycles: A randomized trial |
title_full_unstemmed | Clomiphene citrate versus letrozole with gonadotropins in intrauterine insemination cycles: A randomized trial |
title_short | Clomiphene citrate versus letrozole with gonadotropins in intrauterine insemination cycles: A randomized trial |
title_sort | clomiphene citrate versus letrozole with gonadotropins in intrauterine insemination cycles: a randomized trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340139/ https://www.ncbi.nlm.nih.gov/pubmed/28280800 |
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