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Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma

Oral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. OSCC invasion into the lymph nodes and mandible correlates with increased rates of recurrence and lower overall survival. Tumors that infiltrate mandibular bone proliferate rapidly and induce bone destruction. While survi...

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Detalles Bibliográficos
Autores principales: Cannonier, Shellese A., Gonzales, Cara B., Ely, Kim, Guelcher, Scott A., Sterling, Julie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340177/
https://www.ncbi.nlm.nih.gov/pubmed/27738315
http://dx.doi.org/10.18632/oncotarget.12584