Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity

Ubiquitin-like with PHD and ring finger domains 2 (UHRF2) binds to 5-hydroxymethylcytosine (5hmC), a DNA base involved in tissue development, but it is unknown how their distribution compares with each other in normal and malignant human tissues. We used IHC on human tumor specimens (160 from 19 tum...

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Detalles Bibliográficos
Autores principales: Lu, Huarui, Bhoopatiraju, Sweta, Wang, Hongbo, Schmitz, Nolan P., Wang, Xiaohong, Freeman, Matthew J., Forster, Colleen L., Verneris, Michael R., Linden, Michael A., Hallstrom, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340178/
https://www.ncbi.nlm.nih.gov/pubmed/27738314
http://dx.doi.org/10.18632/oncotarget.12583

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