Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment

Indoleamine 2,3-dioxygenase (IDO) has been implicated in immune evasion by tumors. Upregulation of this tryptophan (Trp)-catabolizing enzyme, in tumor cells and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment (TME), leads to Trp depletion that impairs cytotoxic T cell resp...

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Detalles Bibliográficos
Autores principales: Schafer, Cara C., Wang, Yong, Hough, Kenneth P., Sawant, Anandi, Grant, Stefan C., Thannickal, Victor J., Zmijewski, Jaroslaw, Ponnazhagan, Selvarangan, Deshane, Jessy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340181/
https://www.ncbi.nlm.nih.gov/pubmed/27705910
http://dx.doi.org/10.18632/oncotarget.12249

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