Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer

SMAD4 is an essential mediator in the transforming growth factor-β pathway. Sporadic mutations of SMAD4 are present in 2.1–20.0% of colorectal cancers (CRCs) but data are limited. In this study, we aimed to evaluate clinicopathologic characteristics, prognosis, and clinical outcome associated with t...

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Detalles Bibliográficos
Autores principales: Sarshekeh, Amir Mehrvarz, Advani, Shailesh, Overman, Michael J., Manyam, Ganiraju, Kee, Bryan K., Fogelman, David R., Dasari, Arvind, Raghav, Kanwal, Vilar, Eduardo, Manuel, Shanequa, Shureiqi, Imad, Wolff, Robert A., Patel, Keyur P., Luthra, Raja, Shaw, Kenna, Eng, Cathy, Maru, Dipen M., Routbort, Mark J., Meric-Bernstam, Funda, Kopetz, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340382/
https://www.ncbi.nlm.nih.gov/pubmed/28267766
http://dx.doi.org/10.1371/journal.pone.0173345

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