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Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer: A retrospective study

Epidemiological studies suggest that obesity is a risk of thyroid cancer, especially papillary thyroid cancer (PTC). However, the associations of obesity and clinic–pathological features, especially the association of body mass index (BMI) and lymph node metastasis of thyroid cancer are unclear. Sev...

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Autores principales: Wu, Changhua, Wang, Liang, Chen, Wanjun, Zou, Shujuan, Yang, Aiju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340448/
https://www.ncbi.nlm.nih.gov/pubmed/28248875
http://dx.doi.org/10.1097/MD.0000000000006202
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author Wu, Changhua
Wang, Liang
Chen, Wanjun
Zou, Shujuan
Yang, Aiju
author_facet Wu, Changhua
Wang, Liang
Chen, Wanjun
Zou, Shujuan
Yang, Aiju
author_sort Wu, Changhua
collection PubMed
description Epidemiological studies suggest that obesity is a risk of thyroid cancer, especially papillary thyroid cancer (PTC). However, the associations of obesity and clinic–pathological features, especially the association of body mass index (BMI) and lymph node metastasis of thyroid cancer are unclear. Seven hundred ninety-six primary patients with PTC were enrolled in this retrospective cohort study. The relationships between BMI and clinic-pathological features of PTC were evaluated by logistic regression models based on the 5-point increase in BMI and BMI quartiles (underweight, normal weight, overweight, and obesity). The 5-point increase in BMI was strongly associated with extra-thyroidal invasion [odds ratio (OR) 2.201, P < 0.001], primary tumor size larger than 1 cm (OR 1.267, P = 0.027), advanced tumor node metastasis (TNM) staging (OR 1.479, P = 0.004), and multifocality (OR 1.31, P = 0.01) in multivariable-adjusted models. The relationships between BMI and lymph node metastasis of PTC were evaluated by Mann–Whitney U test. The mean number of positive central lymph nodes and lateral nodes were increased with the increase of BMI when BMI ≥18.5 kg/m(2). It was not shown in underweight group. The present study found that increased BMI was associated with the lymph node metastases (LNMs) of patients with PTC, and other invasive features, including large tumor size, extra-thyroidal invasion, advanced TNM staging, and multifocality. Further studies with long-term follow-up are needed to confirm this finding.
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spelling pubmed-53404482017-03-09 Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer: A retrospective study Wu, Changhua Wang, Liang Chen, Wanjun Zou, Shujuan Yang, Aiju Medicine (Baltimore) 3700 Epidemiological studies suggest that obesity is a risk of thyroid cancer, especially papillary thyroid cancer (PTC). However, the associations of obesity and clinic–pathological features, especially the association of body mass index (BMI) and lymph node metastasis of thyroid cancer are unclear. Seven hundred ninety-six primary patients with PTC were enrolled in this retrospective cohort study. The relationships between BMI and clinic-pathological features of PTC were evaluated by logistic regression models based on the 5-point increase in BMI and BMI quartiles (underweight, normal weight, overweight, and obesity). The 5-point increase in BMI was strongly associated with extra-thyroidal invasion [odds ratio (OR) 2.201, P < 0.001], primary tumor size larger than 1 cm (OR 1.267, P = 0.027), advanced tumor node metastasis (TNM) staging (OR 1.479, P = 0.004), and multifocality (OR 1.31, P = 0.01) in multivariable-adjusted models. The relationships between BMI and lymph node metastasis of PTC were evaluated by Mann–Whitney U test. The mean number of positive central lymph nodes and lateral nodes were increased with the increase of BMI when BMI ≥18.5 kg/m(2). It was not shown in underweight group. The present study found that increased BMI was associated with the lymph node metastases (LNMs) of patients with PTC, and other invasive features, including large tumor size, extra-thyroidal invasion, advanced TNM staging, and multifocality. Further studies with long-term follow-up are needed to confirm this finding. Wolters Kluwer Health 2017-03-03 /pmc/articles/PMC5340448/ /pubmed/28248875 http://dx.doi.org/10.1097/MD.0000000000006202 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 3700
Wu, Changhua
Wang, Liang
Chen, Wanjun
Zou, Shujuan
Yang, Aiju
Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer: A retrospective study
title Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer: A retrospective study
title_full Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer: A retrospective study
title_fullStr Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer: A retrospective study
title_full_unstemmed Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer: A retrospective study
title_short Associations between body mass index and lymph node metastases of patients with papillary thyroid cancer: A retrospective study
title_sort associations between body mass index and lymph node metastases of patients with papillary thyroid cancer: a retrospective study
topic 3700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340448/
https://www.ncbi.nlm.nih.gov/pubmed/28248875
http://dx.doi.org/10.1097/MD.0000000000006202
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