Hereditary Persistence of Alpha-Fetoprotein Is Associated with the −119G>A Polymorphism in AFP Gene

Alpha-fetoprotein (AFP) is a glycoprotein that is produced by the liver and yolk sac during fetal development. Its levels are usually raised in malignant conditions. Hereditary persistence of AFP (HPAFP) is a rare benign condition with elevated levels of AFP. It is inherited in a dominant mode with...

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Autores principales: Deshpande, Neha, Chavan, Radhika, Bale, Govardhan, Avanthi, Urmila Steffie, Aslam, Mohsin, Ramchandani, Mohan, Reddy, D. Nageshwar, Ravikanth, V. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340718/
https://www.ncbi.nlm.nih.gov/pubmed/28286798
http://dx.doi.org/10.14309/crj.2017.33
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author Deshpande, Neha
Chavan, Radhika
Bale, Govardhan
Avanthi, Urmila Steffie
Aslam, Mohsin
Ramchandani, Mohan
Reddy, D. Nageshwar
Ravikanth, V. V.
author_facet Deshpande, Neha
Chavan, Radhika
Bale, Govardhan
Avanthi, Urmila Steffie
Aslam, Mohsin
Ramchandani, Mohan
Reddy, D. Nageshwar
Ravikanth, V. V.
author_sort Deshpande, Neha
collection PubMed
description Alpha-fetoprotein (AFP) is a glycoprotein that is produced by the liver and yolk sac during fetal development. Its levels are usually raised in malignant conditions. Hereditary persistence of AFP (HPAFP) is a rare benign condition with elevated levels of AFP. It is inherited in a dominant mode with complete penetrance and is usually not associated with any clinical disability. We report two individuals with elevated levels of AFP harboring the −119G>A polymorphism in the AFP gene. A genetic screening to rule out variants in the AFP gene is advised in cases with unexplained persistent AFP levels to avoid inappropriate treatment and surgical options.
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spelling pubmed-53407182017-03-10 Hereditary Persistence of Alpha-Fetoprotein Is Associated with the −119G>A Polymorphism in AFP Gene Deshpande, Neha Chavan, Radhika Bale, Govardhan Avanthi, Urmila Steffie Aslam, Mohsin Ramchandani, Mohan Reddy, D. Nageshwar Ravikanth, V. V. ACG Case Rep J Case Report Alpha-fetoprotein (AFP) is a glycoprotein that is produced by the liver and yolk sac during fetal development. Its levels are usually raised in malignant conditions. Hereditary persistence of AFP (HPAFP) is a rare benign condition with elevated levels of AFP. It is inherited in a dominant mode with complete penetrance and is usually not associated with any clinical disability. We report two individuals with elevated levels of AFP harboring the −119G>A polymorphism in the AFP gene. A genetic screening to rule out variants in the AFP gene is advised in cases with unexplained persistent AFP levels to avoid inappropriate treatment and surgical options. American College of Gastroenterology 2017-03-01 /pmc/articles/PMC5340718/ /pubmed/28286798 http://dx.doi.org/10.14309/crj.2017.33 Text en Copyright © Deshpande et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Deshpande, Neha
Chavan, Radhika
Bale, Govardhan
Avanthi, Urmila Steffie
Aslam, Mohsin
Ramchandani, Mohan
Reddy, D. Nageshwar
Ravikanth, V. V.
Hereditary Persistence of Alpha-Fetoprotein Is Associated with the −119G>A Polymorphism in AFP Gene
title Hereditary Persistence of Alpha-Fetoprotein Is Associated with the −119G>A Polymorphism in AFP Gene
title_full Hereditary Persistence of Alpha-Fetoprotein Is Associated with the −119G>A Polymorphism in AFP Gene
title_fullStr Hereditary Persistence of Alpha-Fetoprotein Is Associated with the −119G>A Polymorphism in AFP Gene
title_full_unstemmed Hereditary Persistence of Alpha-Fetoprotein Is Associated with the −119G>A Polymorphism in AFP Gene
title_short Hereditary Persistence of Alpha-Fetoprotein Is Associated with the −119G>A Polymorphism in AFP Gene
title_sort hereditary persistence of alpha-fetoprotein is associated with the −119g>a polymorphism in afp gene
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340718/
https://www.ncbi.nlm.nih.gov/pubmed/28286798
http://dx.doi.org/10.14309/crj.2017.33
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