3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing

Due to its exposure to high concentrations of xenobiotics, the kidney proximal tubule is a primary site of nephrotoxicity and resulting attrition in the drug development pipeline. Current pre-clinical methods using 2D cell cultures and animal models are unable to fully recapitulate clinical drug res...

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Detalles Bibliográficos
Autores principales: King, Shelby M., Higgins, J. William, Nino, Celina R., Smith, Timothy R., Paffenroth, Elizabeth H., Fairbairn, Casey E., Docuyanan, Abigail, Shah, Vishal D., Chen, Alice E., Presnell, Sharon C., Nguyen, Deborah G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340751/
https://www.ncbi.nlm.nih.gov/pubmed/28337147
http://dx.doi.org/10.3389/fphys.2017.00123

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