Cargando…

Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer’s Disease Model Mice Targeting Beta-Amyloid Production

Icariside II (ICS II) is a broad-spectrum anti-cancer natural compound extracted from Herba Epimedii Maxim. Recently, the role of ICS II has been investigated in central nervous system, especially have a neuroprotective effect in Alzheimer’s disease (AD). In this study, we attempted to investigate t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Lingli, Deng, Yuanyuan, Gao, Jianmei, Liu, Yuangui, Li, Fei, Shi, Jingshan, Gong, Qihai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340752/ https://www.ncbi.nlm.nih.gov/pubmed/28337142 http://dx.doi.org/10.3389/fphar.2017.00106

Ejemplares similares

Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats
por: Yin, Caixia, et al.
Publicado: (2018)

Icariside II, a PDE5 Inhibitor, Suppresses Oxygen-Glucose Deprivation/Reperfusion-Induced Primary Hippocampal Neuronal Death Through Activating the PKG/CREB/BDNF/TrkB Signaling Pathway
por: Xu, Fan, et al.
Publicado: (2020)

Icariside II, a Broad-Spectrum Anti-cancer Agent, Reverses Beta-Amyloid-Induced Cognitive Impairment through Reducing Inflammation and Apoptosis in Rats
por: Deng, Yuanyuan, et al.
Publicado: (2017)

Icariside II, a novel phosphodiesterase 5 inhibitor, protects against H(2)O(2)‐induced PC12 cells death by inhibiting mitochondria‐mediated autophagy
por: Gao, Jianmei, et al.
Publicado: (2016)

Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischaemia/reperfusion injury by inhibiting glycogen synthase kinase‐3β‐mediated activation of autophagy
por: Gao, Jianmei, et al.
Publicado: (2020)

Isorhynchophylline Ameliorates Cerebral Ischemia/Reperfusion Injury by Inhibiting CX3CR1-Mediated Microglial Activation and Neuroinflammation
por: Deng, Yuanyuan, et al.
Publicado: (2021)

Icariside II: Anticancer Potential and Molecular Targets in Solid Cancers
por: Xu, Fei, et al.
Publicado: (2021)

Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway
por: Gao, Jianmei, et al.
Publicado: (2018)

CZYH Alleviates β-Amyloid-Induced Cognitive Impairment and Inflammation Response via Modulation of JNK and NF-κB Pathway in Rats
por: Deng, Yuanyuan, et al.
Publicado: (2019)

Icariside II Exerts Anti-Type 2 Diabetic Effect by Targeting PPARα/γ: Involvement of ROS/NF-κB/IRS1 Signaling Pathway
por: Li, Yiqi, et al.
Publicado: (2022)

Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against Myocardial Infarction through the AMPK/PGC-1α/Apoptosis Signaling Pathway
por: Li, Yeli, et al.
Publicado: (2022)

Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of Alzheimer’s disease
por: Mirza, Fatima Javed, et al.
Publicado: (2022)

Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer’s disease
por: Xuan, Aiguo, et al.
Publicado: (2012)

Icariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway
por: Gu, Yang-Yang, et al.
Publicado: (2022)

Activation of Nrf2 signaling: A key molecular mechanism of protection against cardiovascular diseases by natural products
por: Wu, Xiaoyu, et al.
Publicado: (2022)

Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment
por: Wen, Di, et al.
Publicado: (2019)

Icariside II Restores Vascular Smooth Muscle Cell Contractile Phenotype by Enhancing the Focal Adhesion Signaling Pathway in the Rat Vascular Remodeling Model
por: Lv, Junyuan, et al.
Publicado: (2022)

Integrating Experimentation and Quantitative Modeling to Enhance Discovery of Beta Amyloid Lowering Therapeutics for Alzheimer’s Disease
por: Lu, Yasong
Publicado: (2012)

Berberine Ameliorates Spatial Learning Memory Impairment and Modulates Cholinergic Anti-Inflammatory Pathway in Diabetic Rats
por: Wang, Kaifu, et al.
Publicado: (2019)

Impaired Spatial Memory and Enhanced Habit Memory in a Rat Model of Post-traumatic Stress Disorder
por: Goodman, Jarid, et al.
Publicado: (2017)

Trilobatin Protects Against Aβ(25–35)-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent Pathway
por: Chen, Nana, et al.
Publicado: (2020)

Trilobatin, a Naturally Occurring Food Additive, Ameliorates Exhaustive Exercise-Induced Fatigue in Mice: Involvement of Nrf2/ARE/Ferroptosis Signaling Pathway
por: Xiao, Ran, et al.
Publicado: (2022)

Impaired hepatic amyloid-beta degradation in Alzheimer’s disease
por: Maarouf, Chera L., et al.
Publicado: (2018)

Precision Medicine in Alzheimer’s Disease: Investigating Comorbid Common Biological Substrates in the Rat Model of Amyloid Beta-Induced Toxicity
por: Morgese, Maria Grazia, et al.
Publicado: (2022)

The Protective Effects of PSM-04 Against Beta Amyloid-Induced Neurotoxicity in Primary Cortical Neurons and an Animal Model of Alzheimer’s Disease
por: Park, Hyunjun, et al.
Publicado: (2019)

Gastrodin ameliorates subacute phase cerebral ischemia-reperfusion injury by inhibiting inflammation and apoptosis in rats
por: Liu, Bo, et al.
Publicado: (2016)

Comparative Pharmacokinetics Study of Icariin and Icariside II in Rats
por: Cheng, Tao, et al.
Publicado: (2015)

Lentivirus-Carried microRNA-195 Rescues Memory Deficits of Alzheimer’s Disease Transgenic Mouse by Attenuating the Generation of Amyloid Plaques
por: Su, Dan, et al.
Publicado: (2021)

Impaired Spatial Learning and Memory in Middle-Aged Mice with Kindling-Induced Spontaneous Recurrent Seizures
por: Liu, Haiyu, et al.
Publicado: (2019)

Butterbur Leaves Attenuate Memory Impairment and Neuronal Cell Damage in Amyloid Beta-Induced Alzheimer’s Disease Models
por: Kim, Namkwon, et al.
Publicado: (2018)

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease
por: Sun, Xiaojuan, et al.
Publicado: (2015)

Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels
por: Han, Linlin, et al.
Publicado: (2021)

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease
por: Liu, Zun-Jing, et al.
Publicado: (2016)

Doxycycline for Alzheimer’s Disease: Fighting β-Amyloid Oligomers and Neuroinflammation
por: Balducci, Claudia, et al.
Publicado: (2019)

Amyloid-Beta Influences Memory via Functional Connectivity During Memory Retrieval in Alzheimer's Disease
por: Li, Binyin, et al.
Publicado: (2021)

SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer’s Disease Mouse Model
por: Park, Soo Yong, et al.
Publicado: (2020)

Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway
por: Zheng, Yong, et al.
Publicado: (2019)

Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats
por: Guo, Xiying, et al.
Publicado: (2023)

Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats
por: Tian, Wenjie, et al.
Publicado: (2015)

Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells
por: Khan, Muhammad, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ofqsp1ipg1alqpbqq7cs0clar7