MAGE-A Antigens and Cancer Immunotherapy

MAGE-A antigens are expressed in a variety of cancers of diverse histological origin and germinal cells. Due to their relatively high tumor specificity, they represent attractive targets for active specific and adoptive cancer immunotherapies. Here, we (i) review past and ongoing clinical studies ta...

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Detalles Bibliográficos
Autores principales: Zajac, Paul, Schultz-Thater, Elke, Tornillo, Luigi, Sadowski, Charlotte, Trella, Emanuele, Mengus, Chantal, Iezzi, Giandomenica, Spagnoli, Giulio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340762/
https://www.ncbi.nlm.nih.gov/pubmed/28337438
http://dx.doi.org/10.3389/fmed.2017.00018
Descripción
Sumario:MAGE-A antigens are expressed in a variety of cancers of diverse histological origin and germinal cells. Due to their relatively high tumor specificity, they represent attractive targets for active specific and adoptive cancer immunotherapies. Here, we (i) review past and ongoing clinical studies targeting these antigens, (ii) analyze advantages and disadvantages of different therapeutic approaches, and (iii) discuss possible improvements in MAGE-A-specific immunotherapies.

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