MAGE-A Antigens and Cancer Immunotherapy

MAGE-A antigens are expressed in a variety of cancers of diverse histological origin and germinal cells. Due to their relatively high tumor specificity, they represent attractive targets for active specific and adoptive cancer immunotherapies. Here, we (i) review past and ongoing clinical studies ta...

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Autores principales: Zajac, Paul, Schultz-Thater, Elke, Tornillo, Luigi, Sadowski, Charlotte, Trella, Emanuele, Mengus, Chantal, Iezzi, Giandomenica, Spagnoli, Giulio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340762/
https://www.ncbi.nlm.nih.gov/pubmed/28337438
http://dx.doi.org/10.3389/fmed.2017.00018
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author Zajac, Paul
Schultz-Thater, Elke
Tornillo, Luigi
Sadowski, Charlotte
Trella, Emanuele
Mengus, Chantal
Iezzi, Giandomenica
Spagnoli, Giulio C.
author_facet Zajac, Paul
Schultz-Thater, Elke
Tornillo, Luigi
Sadowski, Charlotte
Trella, Emanuele
Mengus, Chantal
Iezzi, Giandomenica
Spagnoli, Giulio C.
author_sort Zajac, Paul
collection PubMed
description MAGE-A antigens are expressed in a variety of cancers of diverse histological origin and germinal cells. Due to their relatively high tumor specificity, they represent attractive targets for active specific and adoptive cancer immunotherapies. Here, we (i) review past and ongoing clinical studies targeting these antigens, (ii) analyze advantages and disadvantages of different therapeutic approaches, and (iii) discuss possible improvements in MAGE-A-specific immunotherapies.
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spelling pubmed-53407622017-03-23 MAGE-A Antigens and Cancer Immunotherapy Zajac, Paul Schultz-Thater, Elke Tornillo, Luigi Sadowski, Charlotte Trella, Emanuele Mengus, Chantal Iezzi, Giandomenica Spagnoli, Giulio C. Front Med (Lausanne) Medicine MAGE-A antigens are expressed in a variety of cancers of diverse histological origin and germinal cells. Due to their relatively high tumor specificity, they represent attractive targets for active specific and adoptive cancer immunotherapies. Here, we (i) review past and ongoing clinical studies targeting these antigens, (ii) analyze advantages and disadvantages of different therapeutic approaches, and (iii) discuss possible improvements in MAGE-A-specific immunotherapies. Frontiers Media S.A. 2017-03-08 /pmc/articles/PMC5340762/ /pubmed/28337438 http://dx.doi.org/10.3389/fmed.2017.00018 Text en Copyright © 2017 Zajac, Schultz-Thater, Tornillo, Sadowski, Trella, Mengus, Iezzi and Spagnoli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zajac, Paul
Schultz-Thater, Elke
Tornillo, Luigi
Sadowski, Charlotte
Trella, Emanuele
Mengus, Chantal
Iezzi, Giandomenica
Spagnoli, Giulio C.
MAGE-A Antigens and Cancer Immunotherapy
title MAGE-A Antigens and Cancer Immunotherapy
title_full MAGE-A Antigens and Cancer Immunotherapy
title_fullStr MAGE-A Antigens and Cancer Immunotherapy
title_full_unstemmed MAGE-A Antigens and Cancer Immunotherapy
title_short MAGE-A Antigens and Cancer Immunotherapy
title_sort mage-a antigens and cancer immunotherapy
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340762/
https://www.ncbi.nlm.nih.gov/pubmed/28337438
http://dx.doi.org/10.3389/fmed.2017.00018
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