Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells

The transcription factor nuclear factor-κB (NF-κB) has important roles for tumorigenesis, but how it regulates cancer stem cells (CSCs) remains largely unclear. We identified insulin-like growth factor 2 (IGF2) is a key target of NF-κB activated by HER2/HER3 signaling to form tumor spheres in breast...

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Detalles Bibliográficos
Autores principales: Tominaga, K, Shimamura, T, Kimura, N, Murayama, T, Matsubara, D, Kanauchi, H, Niida, A, Shimizu, S, Nishioka, K, Tsuji, E-i, Yano, M, Sugano, S, Shimono, Y, Ishii, H, Saya, H, Mori, M, Akashi, K, Tada, K-i, Ogawa, T, Tojo, A, Miyano, S, Gotoh, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340799/
https://www.ncbi.nlm.nih.gov/pubmed/27546618
http://dx.doi.org/10.1038/onc.2016.293

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