The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock

Activation of the NLRP3 inflammasome, which catalyzes maturation of proinflammatory cytokines like IL-1β and IL-18, is implicated and essentially involved in many kinds of inflammatory disorders. Chloroquine (CQ) is a traditional antimalarial drug and also possesses an anti-inflammatory property. In...

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Detalles Bibliográficos
Autores principales: Chen, Xiaoli, Wang, Ning, Zhu, Yuanfeng, Lu, Yongling, Liu, Xin, Zheng, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340938/
https://www.ncbi.nlm.nih.gov/pubmed/28321151
http://dx.doi.org/10.1155/2017/6543237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340938/
https://www.ncbi.nlm.nih.gov/pubmed/28321151
http://dx.doi.org/10.1155/2017/6543237

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