Cargando…

The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock

Activation of the NLRP3 inflammasome, which catalyzes maturation of proinflammatory cytokines like IL-1β and IL-18, is implicated and essentially involved in many kinds of inflammatory disorders. Chloroquine (CQ) is a traditional antimalarial drug and also possesses an anti-inflammatory property. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Xiaoli, Wang, Ning, Zhu, Yuanfeng, Lu, Yongling, Liu, Xin, Zheng, Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340938/ https://www.ncbi.nlm.nih.gov/pubmed/28321151 http://dx.doi.org/10.1155/2017/6543237

Ejemplares similares

miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock
por: Xue, Zhenyi, et al.
Publicado: (2019)

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock
por: Mao, Kairui, et al.
Publicado: (2013)

Mediatory roles of leukotriene B(4) receptors in LPS-induced endotoxic shock
por: Kwon, Sun-Young, et al.
Publicado: (2019)

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome
por: Wang, Zhilei, et al.
Publicado: (2019)

Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome
por: Luo, Jiahui, et al.
Publicado: (2021)

Tim-3 Negatively Mediates Natural Killer Cell Function in LPS-Induced Endotoxic Shock
por: Hou, Hongyan, et al.
Publicado: (2014)

Ablation of Aquaporin-9 Ameliorates the Systemic Inflammatory Response of LPS-Induced Endotoxic Shock in Mouse
por: Tesse, Angela, et al.
Publicado: (2021)

Endotoxic Septic Shock: Diagnosis and Treatment
por: Foster, Debra M., et al.
Publicado: (2023)

Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
por: Liu, Xiaolei, et al.
Publicado: (2021)

Corticosterone Inhibits LPS-Induced NLRP3 Inflammasome Priming in Macrophages by Suppressing Xanthine Oxidase
por: Wu, Ling, et al.
Publicado: (2020)

Zerumbone Suppresses the LPS-Induced Inflammatory Response and Represses Activation of the NLRP3 Inflammasome in Macrophages
por: Su, Chia-Cheng, et al.
Publicado: (2021)

MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
por: Zhao, Qun, et al.
Publicado: (2006)

CD44-Deficiency Attenuates the Immunologic Responses to LPS and Delays the Onset of Endotoxic Shock-Induced Renal Inflammation and Dysfunction
por: Rampanelli, Elena, et al.
Publicado: (2013)

Effects of Ibuprofen on the physiology and outcome of rabbit endotoxic shock
por: Celik, Ilhami, et al.
Publicado: (2002)

Fatal septicemia and endotoxic shock due to Aeromonas hydrophila
por: Takahashi, Nobuyuki, et al.
Publicado: (2012)

Tidal volume in animal models of hemorrhagic and endotoxic shock
por: LIU, FEI, et al.
Publicado: (2013)

Teuvincenone F Suppresses LPS-Induced Inflammation and NLRP3 Inflammasome Activation by Attenuating NEMO Ubiquitination
por: Zhao, Xibao, et al.
Publicado: (2017)

Leukadherin-1-Mediated Activation of CD11b Inhibits LPS-Induced Pro-inflammatory Response in Macrophages and Protects Mice Against Endotoxic Shock by Blocking LPS-TLR4 Interaction
por: Yao, Xiaoying, et al.
Publicado: (2019)

Antimalarials (chloroquine and hydroxychloroquine) in the COVID-19 pandemic()
por: Jáuregui, Edwin
Publicado: (2021)

Mycotoxin Zearalenone Attenuates Innate Immune Responses and Suppresses NLRP3 Inflammasome Activation in LPS-Activated Macrophages
por: Lee, Po-Yen, et al.
Publicado: (2021)

Korean Red Ginseng Saponin Fraction Downregulates Proinflammatory Mediators in LPS Stimulated RAW264.7 Cells and Protects Mice against Endotoxic Shock
por: Yayeh, Taddessee, et al.
Publicado: (2012)

Interferon gamma receptor deficient mice are resistant to endotoxic shock
Publicado: (1994)

Intravascular heavy chain-modification of hyaluronan during endotoxic shock
por: Ni, Kevin, et al.
Publicado: (2018)

Lobeglitazone inhibits LPS-induced NLRP3 inflammasome activation and inflammation in the liver
por: Seo, Hye-Young, et al.
Publicado: (2023)

Sulfasalazine treatment can cause a positive effect on LPS-induced endotoxic rats
por: Dik, Burak, et al.
Publicado: (2018)

Halobacterial nano vesicles displaying murine bactericidal permeability-increasing protein rescue mice from lethal endotoxic shock
por: Balakrishnan, Arjun, et al.
Publicado: (2016)

Progress in the development of Reversed Chloroquine molecules as antimalarial therapy
por: Burgess, Steven J, et al.
Publicado: (2010)

The Antimalarial Chloroquine Reduces the Burden of Persistent Atrial Fibrillation
por: Tobón, Catalina, et al.
Publicado: (2019)

Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter
por: Egan, Timothy J, et al.
Publicado: (2013)

Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A
por: Panayiotou, Catherine M, et al.
Publicado: (2010)

ECMO Maintains Cerebral Blood Flow During Endotoxic Shock in Piglets
por: Batts, Sherreen G., et al.
Publicado: (2016)

The influence of esmolol on right ventricular function in early experimental endotoxic shock
por: van Loon, Lex M., et al.
Publicado: (2018)

Author correction to ‘Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome’ [Acta Pharmaceutica Sinica B 9 (2019) 734–744]
por: Wang, Zhilei, et al.
Publicado: (2020)

NLRP12 Inflammasome Expression in the Rat Brain in Response to LPS during Morphine Tolerance
por: Chang, Sulie L., et al.
Publicado: (2017)

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis
por: Marchetti, Carlo, et al.
Publicado: (2018)

Induction of TLR4/TLR2 Interaction and Heterodimer Formation by Low Endotoxic Atypical LPS
por: Francisco, Sara, et al.
Publicado: (2022)

The Novel Role of Platelet-Activating Factor in Protecting Mice against Lipopolysaccharide-Induced Endotoxic Shock
por: Jeong, Young-Il, et al.
Publicado: (2009)

Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation
por: Yoo, Chae-Hwa, et al.
Publicado: (2014)

Interferon Regulatory Factor 6 Has a Protective Role in the Host Response to Endotoxic Shock
por: Joly, Sophie, et al.
Publicado: (2016)

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii
por: Gorfu, Gezahegn, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_nr306tq2umbvidu80gk30ijs85