Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa

Historically, the colistin has been thought to kill bacteria through membrane lysis. Here, we present an alternative mechanism that colistin induces rapid Paenibacillus polymyxa death through reactive oxygen species production. This significantly augments our understanding of the mechanism of colist...

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Detalles Bibliográficos
Autores principales: Yu, Zhiliang, Zhu, Yuyi, Qin, Wangrong, Yin, Jianhua, Qiu, Juanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340943/
https://www.ncbi.nlm.nih.gov/pubmed/28321410
http://dx.doi.org/10.1155/2017/5437139
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author Yu, Zhiliang
Zhu, Yuyi
Qin, Wangrong
Yin, Jianhua
Qiu, Juanping
author_facet Yu, Zhiliang
Zhu, Yuyi
Qin, Wangrong
Yin, Jianhua
Qiu, Juanping
author_sort Yu, Zhiliang
collection PubMed
description Historically, the colistin has been thought to kill bacteria through membrane lysis. Here, we present an alternative mechanism that colistin induces rapid Paenibacillus polymyxa death through reactive oxygen species production. This significantly augments our understanding of the mechanism of colistin action, which is critical knowledge toward the yield development of colistin in the future.
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spelling pubmed-53409432017-03-20 Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa Yu, Zhiliang Zhu, Yuyi Qin, Wangrong Yin, Jianhua Qiu, Juanping Biomed Res Int Research Article Historically, the colistin has been thought to kill bacteria through membrane lysis. Here, we present an alternative mechanism that colistin induces rapid Paenibacillus polymyxa death through reactive oxygen species production. This significantly augments our understanding of the mechanism of colistin action, which is critical knowledge toward the yield development of colistin in the future. Hindawi Publishing Corporation 2017 2017-02-22 /pmc/articles/PMC5340943/ /pubmed/28321410 http://dx.doi.org/10.1155/2017/5437139 Text en Copyright © 2017 Zhiliang Yu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yu, Zhiliang
Zhu, Yuyi
Qin, Wangrong
Yin, Jianhua
Qiu, Juanping
Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa
title Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa
title_full Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa
title_fullStr Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa
title_full_unstemmed Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa
title_short Oxidative Stress Induced by Polymyxin E Is Involved in Rapid Killing of Paenibacillus polymyxa
title_sort oxidative stress induced by polymyxin e is involved in rapid killing of paenibacillus polymyxa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340943/
https://www.ncbi.nlm.nih.gov/pubmed/28321410
http://dx.doi.org/10.1155/2017/5437139
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