Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-ι

N1-methyl-deoxyadenosine (1-MeA) is formed by methylation of deoxyadenosine at the N1 atom. 1-MeA presents a block to replicative DNA polymerases due to its inability to participate in Watson-Crick (W-C) base pairing. Here we determine how human DNA polymerase-ι (Polι) promotes error-free replicatio...

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Detalles Bibliográficos
Autores principales: Jain, Rinku, Choudhury, Jayati Roy, Buku, Angeliki, Johnson, Robert E., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341039/
https://www.ncbi.nlm.nih.gov/pubmed/28272441
http://dx.doi.org/10.1038/srep43904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341039/
https://www.ncbi.nlm.nih.gov/pubmed/28272441
http://dx.doi.org/10.1038/srep43904

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