Cargando…

Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-ι

N1-methyl-deoxyadenosine (1-MeA) is formed by methylation of deoxyadenosine at the N1 atom. 1-MeA presents a block to replicative DNA polymerases due to its inability to participate in Watson-Crick (W-C) base pairing. Here we determine how human DNA polymerase-ι (Polι) promotes error-free replicatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jain, Rinku, Choudhury, Jayati Roy, Buku, Angeliki, Johnson, Robert E., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341039/ https://www.ncbi.nlm.nih.gov/pubmed/28272441 http://dx.doi.org/10.1038/srep43904

Ejemplares similares

DNA polymerase λ promotes error-free replication through Watson–Crick impairing N1-methyl-deoxyadenosine adduct in conjunction with DNA polymerase ζ
por: Yoon, Jung-Hoon, et al.
Publicado: (2021)

Crystal Structure of Yeast DNA Polymerase ε Catalytic Domain
por: Jain, Rinku, et al.
Publicado: (2014)

Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine
por: Rechkoblit, Olga, et al.
Publicado: (2018)

Structural basis for cisplatin DNA damage tolerance by human polymerase η during cancer chemotherapy
por: Ummat, Ajay, et al.
Publicado: (2012)

Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η
por: Rechkoblit, Olga, et al.
Publicado: (2019)

Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ
por: Yoon, Jung-Hoon, et al.
Publicado: (2015)

Structure and Mechanism of B-family DNA Polymerase ζ Specialized for Translesion DNA Synthesis
por: Malik, Radhika, et al.
Publicado: (2020)

Human DNA polymerase α in binary complex with a DNA:DNA template-primer
por: Coloma, Javier, et al.
Publicado: (2016)

Structure of Human DNA Polymerase κ Inserting dATP Opposite an 8-OxoG DNA Lesion
por: Carpio, Rodrigo Vasquez-Del, et al.
Publicado: (2009)

Structural basis of high fidelity DNA synthesis by yeast DNA polymerase delta
por: Swan, Michael K., et al.
Publicado: (2009)

Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch
por: Malik, Radhika, et al.
Publicado: (2022)

Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
por: Rechkoblit, Olga, et al.
Publicado: (2021)

Posttranslational Regulation of Human DNA Polymerase ι
por: McIntyre, Justyna, et al.
Publicado: (2015)

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity
por: Rechkoblit, Olga, et al.
Publicado: (2016)

Biochemical Analysis of Six Genetic Variants of Error-Prone Human DNA Polymerase ι Involved in Translesion DNA Synthesis
por: Kim, Jinsook, et al.
Publicado: (2014)

Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase
por: Rechkoblit, Olga, et al.
Publicado: (2017)

DNA polymerase ι is acetylated in response to S(N)2 alkylating agents
por: McIntyre, Justyna, et al.
Publicado: (2019)

A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζ
por: Yoon, Jung-Hoon, et al.
Publicado: (2021)

Yeast 9-1-1 complex acts as a sliding clamp for DNA synthesis by DNA polymerase ε
por: Acharya, Narottam, et al.
Publicado: (2022)

The Steric Gate of DNA Polymerase ι Regulates Ribonucleotide Incorporation and Deoxyribonucleotide Fidelity
por: Donigan, Katherine A., et al.
Publicado: (2014)

Enzymatic bypass of an N(6)-deoxyadenosine DNA–ethylene dibromide–peptide cross-link by translesion DNA polymerases
por: Ghodke, Pratibha P., et al.
Publicado: (2021)

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications
por: Koziol, Magdalena J., et al.
Publicado: (2015)

Ubiquitin mediates the physical and functional interaction between human DNA polymerases η and ι
por: McIntyre, Justyna, et al.
Publicado: (2013)

DNA polymerase ε leading strand signature mutations result from defects in its proofreading activity
por: Johnson, Robert E., et al.
Publicado: (2023)

129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation
por: McDonald, John P., et al.
Publicado: (2003)

DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes
por: Maul, Robert W., et al.
Publicado: (2016)

DNA polymerase iota (Pol ι) promotes invasion and metastasis of esophageal squamous cell carcinoma
por: Zou, Shitao, et al.
Publicado: (2016)

Implications of inhibition of Rev1 interaction with Y family DNA polymerases for cisplatin chemotherapy
por: Yoon, Jung-Hoon, et al.
Publicado: (2021)

DNA Polymerase ι Interacts with Both the TRAF-like and UBL1-2 Domains of USP7
por: Ashton, Nicholas W., et al.
Publicado: (2020)

Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability
por: Mansilla, Sabrina F., et al.
Publicado: (2023)

Eukaryotic Y-family polymerases bypass a 3-methyl-2′-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivo
por: Plosky, Brian S., et al.
Publicado: (2008)

DNA polymerase θ accomplishes translesion synthesis opposite 1,N(6)-ethenodeoxyadenosine with a remarkably high fidelity in human cells
por: Yoon, Jung-Hoon, et al.
Publicado: (2019)

In Vitro Bypass of the Major Malondialdehyde- and Base Propenal-Derived DNA Adduct by Human Y-family DNA Polymerases κ, ι, and Rev1
por: Maddukuri, Leena, et al.
Publicado: (2010)

DNA polymerase δ proofreads errors made by DNA polymerase ε
por: Bulock, Chelsea R., et al.
Publicado: (2020)

Contiguous 2,2,4-triamino-5(2H)-oxazolone obstructs DNA synthesis by DNA polymerases α, β, η, ι, κ, REV1 and Klenow Fragment exo(−), but not by DNA polymerase ζ
por: Suzuki, Masayo, et al.
Publicado: (2016)

Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine
por: Balachander, Sathya, et al.
Publicado: (2020)

Nuclear magnetic resonance spectral data of the USP7 TRAF and UBL1-2 domains in complex with DNA polymerase ι peptides
por: Valles, Gabrielle J., et al.
Publicado: (2020)

RNA binding to human METTL3-METTL14 restricts N(6)-deoxyadenosine methylation of DNA in vitro
por: Qi, Shan, et al.
Publicado: (2022)

Chemical synthesis, DNA incorporation and biological study of a new photocleavable 2′-deoxyadenosine mimic
por: Berthet, Nathalie, et al.
Publicado: (2009)

Incorporation characteristics of exogenous (15)N-labeled thymidine, deoxyadenosine, deoxyguanosine and deoxycytidine into bacterial DNA
por: Tsuchiya, Kenji, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e4qddauli1s56qup5dd34ck3lr