Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells

Centrosome aberrations (CA) and abnormal mitoses are considered beacons of malignancy. Cancer cell doubling times in patient tumors are longer than in cultures, but differences in CA between tumors and cultured cells are uncharacterized. We compare mitoses and CA in patient tumors, xenografts, and t...

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Detalles Bibliográficos
Autores principales: Mittal, Karuna, Choi, Da Hoon, Ogden, Angela, Donthamsetty, Shashi, Melton, Brian D., Gupta, Meenakshi. V., Pannu, Vaishali, Cantuaria, Guilherme, Varambally, Sooryanarayana, Reid, Michelle D., Jonsdottir, Kristin, Janssen, Emiel A. M., Aleskandarany, Mohammad A., Ellis, Ian O., Rakha, Emad A., Rida, Padmashree C. G., Aneja, Ritu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341055/
https://www.ncbi.nlm.nih.gov/pubmed/28272508
http://dx.doi.org/10.1038/srep43984

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