O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans

In C. elegans, the transcription factor skinhead-1 (SKN-1), the ortholog of human NF-E2-related factor 2 (Nrf-2), plays important roles in oxidative stress defense and aging processes. It has been documented that the activity of SKN-1 is regulated by its phosphorylation modification. However, whethe...

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Detalles Bibliográficos
Autores principales: Li, Hongyuan, Liu, Xin, Wang, Dan, Su, Liangping, Zhao, Tingting, Li, Zhongwei, Lin, Cong, Zhang, Yu, Huang, Baiqu, Lu, Jun, Li, Xiaoxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341102/
https://www.ncbi.nlm.nih.gov/pubmed/28272406
http://dx.doi.org/10.1038/srep43601

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