Post-translational modifications in PrP expand the conformational diversity of prions in vivo

Misfolded prion protein aggregates (PrP(Sc)) show remarkable structural diversity and are associated with highly variable disease phenotypes. Similarly, other proteins, including amyloid-β, tau, α-synuclein, and serum amyloid A, misfold into distinct conformers linked to different clinical diseases...

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Detalles Bibliográficos
Autores principales: Aguilar-Calvo, Patricia, Xiao, Xiangzhu, Bett, Cyrus, Eraña, Hasier, Soldau, Katrin, Castilla, Joaquin, Nilsson, K. Peter R., Surewicz, Witold K., Sigurdson, Christina J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341109/
https://www.ncbi.nlm.nih.gov/pubmed/28272426
http://dx.doi.org/10.1038/srep43295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341109/
https://www.ncbi.nlm.nih.gov/pubmed/28272426
http://dx.doi.org/10.1038/srep43295

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