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Mucosal delivery of anti-inflammatory IL-1Ra by sporulating recombinant bacteria

BACKGROUND: Mucosal delivery of therapeutic protein drugs or vaccines is actively investigated, in order to improve bioavailability and avoid side effects associated with systemic administration. Orally administered bacteria, engineered to produce anti-inflammatory cytokines (IL-10, IL-1Ra), have sh...

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Detalles Bibliográficos
Autores principales:	Porzio, Stefano, Bossù, Paola, Ruggiero, Paolo, Boraschi, Diana, Tagliabue, Aldo
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2004
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC534112/ https://www.ncbi.nlm.nih.gov/pubmed/15516267 http://dx.doi.org/10.1186/1472-6750-4-27

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