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Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome

Apolipoprotein E4 (E4) and type 2 diabetes are major risk factors for cognitive decline and late onset Alzheimer’s disease (AD). E4-associated phenotypes and insulin resistance (IR) share several features and appear to interact in driving cognitive dysfunction. However, shared mechanisms that could...

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Detalles Bibliográficos
Autores principales:	Johnson, Lance A., Torres, Eileen Ruth S., Impey, Soren, Stevens, Jan F., Raber, Jacob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341123/ https://www.ncbi.nlm.nih.gov/pubmed/28272510 http://dx.doi.org/10.1038/srep43701

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