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The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

BACKGROUND: Gab1 is a docking protein that recruits phosphatidylinositol-3 kinase (PI-3 kinase) and other effector proteins in response to the activation of many receptor tyrosine kinases (RTKs). As the autophosphorylation sites on EGF-receptor (EGFR) do not include canonical PI-3 kinase binding sit...

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Detalles Bibliográficos
Autores principales:	Mattoon, Dawn R, Lamothe, Betty, Lax, Irit, Schlessinger, Joseph
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2004
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC534114/ https://www.ncbi.nlm.nih.gov/pubmed/15550174 http://dx.doi.org/10.1186/1741-7007-2-24

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