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Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease

INTRODUCTION: Hippocampus undergoes atrophy in patients with Alzheimer's disease (AD). Calculation of hippocampal volumes can be done by a variety of methods using T1-weighted images of magnetic resonance imaging (MRI) of the brain. Medial temporal lobes atrophy (MTL) can be rated visually usin...

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Autores principales: Dhikav, Vikas, Duraiswamy, Sharmila, Anand, Kuljeet Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341264/
https://www.ncbi.nlm.nih.gov/pubmed/28298839
http://dx.doi.org/10.4103/0972-2327.199903
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author Dhikav, Vikas
Duraiswamy, Sharmila
Anand, Kuljeet Singh
author_facet Dhikav, Vikas
Duraiswamy, Sharmila
Anand, Kuljeet Singh
author_sort Dhikav, Vikas
collection PubMed
description INTRODUCTION: Hippocampus undergoes atrophy in patients with Alzheimer's disease (AD). Calculation of hippocampal volumes can be done by a variety of methods using T1-weighted images of magnetic resonance imaging (MRI) of the brain. Medial temporal lobes atrophy (MTL) can be rated visually using T1-weighted MRI brain images. The present study was done to see if any correlation existed between hippocampal volumes and visual rating scores of the MTL using Scheltens Visual Rating Method. MATERIALS AND METHODS: We screened 84 subjects presented to the Department of Neurology of a Tertiary Care Hospital and enrolled forty subjects meeting the National Institute of Neurological and Communicative Disorders and Stroke, AD related Disease Association criteria. Selected patients underwent MRI brain and T1-weighted images in a plane perpendicular to long axis of hippocampus were obtained. Hippocampal volumes were calculated manually using a standard protocol. The calculated hippocampal volumes were correlated with Scheltens Visual Rating Method for Rating MTL. A total of 32 cognitively normal age-matched subjects were selected to see the same correlation in the healthy subjects as well. Sensitivity and specificity of both methods was calculated and compared. RESULTS: There was an insignificant correlation between the hippocampal volumes and MTL rating scores in cognitively normal elderly (n = 32; Pearson Correlation coefficient = 0.16, P > 0.05). In the AD Group, there was a moderately strong correlation between measured hippocampal volumes and MTL Rating (Pearson's correlation coefficient = −0.54; P < 0.05. There was a moderately strong correlation between hippocampal volume and Mini-Mental Status Examination in the AD group. Manual delineation was superior compared to the visual method (P < 0.05). CONCLUSIONS: Good correlation was present between manual hippocampal volume measurements and MTL scores. Sensitivity and specificity of manual measurement of hippocampus was higher compared to visual rating scores for MTL in patients with AD.
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spelling pubmed-53412642017-03-15 Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease Dhikav, Vikas Duraiswamy, Sharmila Anand, Kuljeet Singh Ann Indian Acad Neurol Original Article INTRODUCTION: Hippocampus undergoes atrophy in patients with Alzheimer's disease (AD). Calculation of hippocampal volumes can be done by a variety of methods using T1-weighted images of magnetic resonance imaging (MRI) of the brain. Medial temporal lobes atrophy (MTL) can be rated visually using T1-weighted MRI brain images. The present study was done to see if any correlation existed between hippocampal volumes and visual rating scores of the MTL using Scheltens Visual Rating Method. MATERIALS AND METHODS: We screened 84 subjects presented to the Department of Neurology of a Tertiary Care Hospital and enrolled forty subjects meeting the National Institute of Neurological and Communicative Disorders and Stroke, AD related Disease Association criteria. Selected patients underwent MRI brain and T1-weighted images in a plane perpendicular to long axis of hippocampus were obtained. Hippocampal volumes were calculated manually using a standard protocol. The calculated hippocampal volumes were correlated with Scheltens Visual Rating Method for Rating MTL. A total of 32 cognitively normal age-matched subjects were selected to see the same correlation in the healthy subjects as well. Sensitivity and specificity of both methods was calculated and compared. RESULTS: There was an insignificant correlation between the hippocampal volumes and MTL rating scores in cognitively normal elderly (n = 32; Pearson Correlation coefficient = 0.16, P > 0.05). In the AD Group, there was a moderately strong correlation between measured hippocampal volumes and MTL Rating (Pearson's correlation coefficient = −0.54; P < 0.05. There was a moderately strong correlation between hippocampal volume and Mini-Mental Status Examination in the AD group. Manual delineation was superior compared to the visual method (P < 0.05). CONCLUSIONS: Good correlation was present between manual hippocampal volume measurements and MTL scores. Sensitivity and specificity of manual measurement of hippocampus was higher compared to visual rating scores for MTL in patients with AD. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5341264/ /pubmed/28298839 http://dx.doi.org/10.4103/0972-2327.199903 Text en Copyright: © 2006 - 2017 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Dhikav, Vikas
Duraiswamy, Sharmila
Anand, Kuljeet Singh
Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease
title Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease
title_full Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease
title_fullStr Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease
title_full_unstemmed Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease
title_short Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease
title_sort correlation between hippocampal volumes and medial temporal lobe atrophy in patients with alzheimer's disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341264/
https://www.ncbi.nlm.nih.gov/pubmed/28298839
http://dx.doi.org/10.4103/0972-2327.199903
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