Compound genetically engineered mouse models of cancer reveal dual targeting of ALK1 and endoglin as a synergistic opportunity to impinge on angiogenic TGF-β signaling

Angiogenesis occurs early in tumor development, sustains primary tumor growth and provides a route for metastatic escape. The TGF-β family receptors modulate angiogenesis via endothelial-cell specific pathways. Here we investigate the interaction of two such receptors, ALK1 and endoglin, in pancreat...

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Detalles Bibliográficos
Autores principales: Eleftheriou, Nikolas M., Sjölund, Jonas, Bocci, Matteo, Cortez, Eliane, Lee, Se-Jin, Cunha, Sara I., Pietras, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341292/
https://www.ncbi.nlm.nih.gov/pubmed/27741515
http://dx.doi.org/10.18632/oncotarget.12604

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