Comparative evaluation of coenzyme Q(10)-based gel and 0.8% hyaluronic acid gel in treatment of chronic periodontitis

BACKGROUND: The anti-inflammatory and immune enhancing effects of coenzyme Q(10) (CoQ(10)) and hyaluronic acid are well established in medical literature. The present study was undertaken to evaluate their role in chronic periodontitis. MATERIALS AND METHODS: One hundred twenty sites in 24 patients with clinically confirmed periodontitis were included in the study. A split-mouth design was used for intrasulcular application of CoQ(10) as adjunct to scaling and root planing (SRP), 0.8% hyaluronic acid as adjunct to SRP and SRP alone. Clinical parameters such as plaque index (PI), gingival color change index (GCCI), Eastman interdental bleeding index (EIBI), pocket depth (PD), and clinical attachment level (CAL) were recorded. All the clinical parameters PI, EIBI, GCCI, PD, and CAL were recorded at baseline before SRP. Only PI, EIBI, and GCCI were recorded at 1(st) and 2(nd) week. Twenty-one days post 2(nd) week, i.e., 6(th) week all the clinical parameters were recorded again. RESULTS: Intragroup analysis of all the clinical parameters showed clinical significant results between baseline and 6(th) week. However, on intergroup analysis, the results were not significant. CONCLUSION: The local application of CoQ(10) and hyaluronic acid gel in conjunction with SRP may have a beneficial effect on periodontal health in patients with chronic periodontitis.